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Cardiovascular sequelae of radiation therapy

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Abstract

Radiotherapy (RT) is one of the main therapeutic options for malignancy treatment; nevertheless, RT is not free from side effects, including an increased risk for secondary neoplasms and other organs injury. Cardiovascular complications are the second most frequent fatal post-RT sequelae, which physicians should be aware of and ready to diagnose early and cure. This review therefore aims to examine epidemiology, pathogenesis and clinical dose-correlated manifestations of RT-induced cardiovascular disease. Future perspectives on screening, prevention and treatment are also provided.

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Authors and Affiliations

  1. Cardiology Department, University of Foggia, Viale Pinto 1, 71100, Foggia, Italy

    Francesco Santoro, Nicola Tarantino, Pier Luigi Pellegrino, Marica Caivano, Agostino Lopizzo, Matteo Di Biase & Natale Daniele Brunetti

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  1. Francesco Santoro
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  2. Nicola Tarantino
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  3. Pier Luigi Pellegrino
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Correspondence to Natale Daniele Brunetti.

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Santoro, F., Tarantino, N., Pellegrino, P.L. et al. Cardiovascular sequelae of radiation therapy. Clin Res Cardiol 103, 955–967 (2014). https://doi.org/10.1007/s00392-014-0718-y

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