Skip to main content
SpringerLink
Log in

Brain tissue oxygenation index measured by near infrared spatially resolved spectroscopy agreed with jugular bulb oxygen saturation in normal pediatric brain: a pilot study

  • Original Paper
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Objectives

This observational, prospective pediatric human study was performed to determine the agreement between brain tissue oxygenation indices (TOI) measured by near infrared spatially resolved spectroscopy and jugular bulb oxygen saturation values (SjO2).

Methods

Five cardiac patients without neurological impairment who were admitted into the critical care unit after open-heart surgery with jugular bulb venous catheters were enrolled. Their mean age was 8.6 months and mean body weight was 6.7 kg. Simultaneous measurements of brain TOI using NIR0-300 (Hamamatsu Photonics, Hamamatsu City, Japan) and SjO2 values from blood samples were recorded.

Results

The TOI range was 59±9% and the SjO2 range was 58±17%. The correlation coefficient R was 0.64 (p=0.11; n=14). Bland–Altman plotting revealed a bias of −3.4%, and precision of 7.2% (n=14). Intra-class correlation reliability analysis showed kappa of 0.55.

Conclusion

Statistically, brain TOI was in reasonable agreement with SjO2 in pediatric patients with normal brain within the measurement range from 50 to 70%.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Smythe PR, Samra SK (2002) Monitors of cerebral oxygenation. Anesthesiol Clin North Am 20:293–313

    Google Scholar 

  2. Cruz J (1998) The first decade of continuous monitoring of jugular bulb oxyhemoglobin saturation: management strategies and clinical outcome. Crit Care Med 26:344–351

    Google Scholar 

  3. Gopinath SP, Robertson CS, Chance B et al (1995) Early detection of delayed traumatic intracranial hematomas using near infrared spectroscopy. J Neurosurg 83:438–444

    Google Scholar 

  4. Keller E, Nadler A, Yonekawa Y (2002) New methods for monitoring cerebral oxygenation and hemodynamics in patients with subarachnoid hemorrhage. Acta Neurochir Suppl 82:87–92

    Google Scholar 

  5. Nielsen HB, Larsen FS (2003) Cerebral oxygenation determined by near-infrared spectrophotometry in patients with fulminant hepatic failure. J Hepatol 38:188–192

    Google Scholar 

  6. Kirkpatrick PJ, Smielewski P, Pickard JD et al (1995) Near infrared spectroscopy use in patients with head injury. J Neurosurg 83:963–970

    Google Scholar 

  7. Jobsis FF (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198:1264–1267

    CAS  PubMed  Google Scholar 

  8. Bissonnette B, Gilder F, Black M et al (2000) Cerebral hyperthermia in children after cardiopulmonary bypass. Anesthesiology 93:611–618

    Google Scholar 

  9. Goetting MG, Preston G (1990) Jugular bulb catheterization: experience with 123 patients. Crit Care Med 18:1220–1223

    Google Scholar 

  10. Van der Zee P, Cope M, Reynolds EO et al (1992) Experimentally measured optical pathlengths for the adult head, calf and forearm and the head of the newborn infant as a function of interoptode spacing. Adv Exp Med Biol 316:143–153

    Google Scholar 

  11. Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1(8476):307–310

    CAS  PubMed  Google Scholar 

  12. Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174

    CAS  PubMed  Google Scholar 

  13. Cope M, Delpy DT (1988) A system for long-term measurement of cerebral blood and tissue oxygenation in newborn infants by near infrared transillumination. Med Biol Eng Comput 26:289–294

    Google Scholar 

  14. Suzuki S, Ozaki T, Kobayashi Y et al (1999) A tissue oxygenation monitor using NIR spatially resolved spectroscopy. Proc SPIE 3597:582–592

    Article  CAS  Google Scholar 

  15. Watzman HM, Kurth CD, Nicolson SC et al (2000) Arterial and venous contributions to near infrared cerebral oximetry. Anesthesiology 93:947–953

    Google Scholar 

  16. Daubeney PEF, Pilkington SN, Webber SA et al (1996) Cerebral oxygenation measured by near-infrared spectroscopy: comparison with jugular bulb oximetry. Ann Thorac Surg 61:930–934

    Article  CAS  PubMed  Google Scholar 

  17. Ali MS, Harmer M, Latto IP et al (2001) Spatially resolved spectroscopy does not agree with jugular bulb oxygen saturation in patients undergoing warm bypass surgery. Can J Anaesth 48:497–501

    CAS  PubMed  Google Scholar 

  18. Van den Brink WA, Van Santbrink H, Maas AIR et al (2000) Brain oxygen tension in severe head injury. Neurosurgery 46:868–876

    Google Scholar 

  19. Lam JM, Chan MS, Poon WS (1996) Cerebral venous oxygen saturation monitoring: is dominant jugular bulb cannulation good enough? Br J Neurosurg 10:357–364

    Google Scholar 

  20. Metz C, Holzschuh M, Brawanski A et al (1998) Monitoring of cerebral oxygen metabolism in the jugular bulb: reliability of unilateral measurement in severe head injury. J Cereb Blood Flow Metab 18:332–343

    Google Scholar 

Download references

Acknowledgements

The authors highly appreciate Dr. Derec Stephan for his suggestions and statistical analysis of this work.

Author information

Authors and Affiliations

  1. Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

    Naoki Shimizu, Desmond Bohn & Katsuyuki Miyasaka

  2. Department of Anesthesia and ICU, National Children’s Medical Center, National Center for Child Health and Development, Tokyo, Japan

    Naoki Shimizu & Katsuyuki Miyasaka

  3. Department of Anesthesia, The Hospital for Sick Children, Toronto, Ontario, Canada

    Fay Gilder & Bruno Bissonnette

  4. Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada

    John Coles

Authors
  1. Naoki Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fay Gilder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bruno Bissonnette
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. John Coles
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Desmond Bohn
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Katsuyuki Miyasaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naoki Shimizu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shimizu, N., Gilder, F., Bissonnette, B. et al. Brain tissue oxygenation index measured by near infrared spatially resolved spectroscopy agreed with jugular bulb oxygen saturation in normal pediatric brain: a pilot study. Childs Nerv Syst 21, 181–184 (2005). https://doi.org/10.1007/s00381-004-1079-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-004-1079-z

Keywords

Search

Navigation