Abstract
A 20-year-old female was admitted with tophus gout and chronic kidney disease (CKD), progressing to dialysis need and death. The familial investigation evidenced several cases of hyperuricemia, gout and CKD, as well as several cases of early death due to CKD. After analyzing these cases, it was concluded that the diagnosis was familial juvenile hyperuricemic nephropathy. This is an autosomal dominant disorder caused by mutations in the uromodulin gene, characterized by early beginning hyperuricemia and gout, in men and women, associated with progressive CKD.
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Acknowledgments
We are very grateful to the team of physicians, nurses and medical students of the Walter Cantídio University Hospital for the assistance provided to the patients.
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Medeiros, M.M.C., Silva, G.B. & Daher, E.F. Tophus gout and chronic kidney disease in a young female patient: report of familial juvenile hyperuricemic nephropathy in three generations of the same family. Rheumatol Int 32, 3687–3690 (2012). https://doi.org/10.1007/s00296-011-2106-5
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DOI: https://doi.org/10.1007/s00296-011-2106-5