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Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria

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Abstract

Toll-like receptors (TLRs) are important to initiate the innate immune response to a wide variety of pathogens. The protective role of TLRs during infection with protozoan parasites has been established. In this regard, malaria represents an exception where activation of TLRs seems to be deleterious to the host. In this article, we review the recent findings indicating the contrasting role of Myeloid Differentiation Primary-Response gene 88 (MyD88) and TLRs during malaria and infection with other protozoa. These findings suggest that MyD88 may represent an Achilles’ heel during Plasmodium infection.

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Acknowledgements

The R.T.G. laboratory is funded by Fundação de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), the US National Institutes of Health (NIH), the World Health Organization, and the Millenium Institute for Vaccine Technology and Development. R.T.G. is a recipient of fellowships from Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico and the John Simon Guggenheim Memorial Foundation. C.R. and B.S.F. received research fellowships from FAPEMIG and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), respectively.

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Authors and Affiliations

  1. Laboratory of Immunopathology, René Rachou Institute, FIOCRUZ, Av. Augusto de Lima, 1715, Belo Horizonte, MG, Brazil

    Catherine Ropert, Bernardo S. Franklin & Ricardo T. Gazzinelli

  2. Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, MG, Brazil

    Ricardo T. Gazzinelli

  3. Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 302, Worcester, MA, 01605, USA

    Ricardo T. Gazzinelli

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  1. Catherine Ropert
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  2. Bernardo S. Franklin
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  3. Ricardo T. Gazzinelli
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Correspondence to Catherine Ropert.

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Ropert, C., Franklin, B.S. & Gazzinelli, R.T. Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria. Semin Immunopathol 30, 41–51 (2008). https://doi.org/10.1007/s00281-007-0103-2

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  • DOI: https://doi.org/10.1007/s00281-007-0103-2

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