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Neuroophthalmological side effects following intrathecal administration of liposomal cytarabine for central nervous system prophylaxis in three adolescents with acute myeloid leukaemia

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Abstract

Three adolescents with central nervous system (CNS) negative acute myeloid leukaemia (AML) refused cranial irradiation for CNS prophylaxis. Instead, these patients received four doses of 50 mg of intrathecal (IT) liposomal cytarabine on day 1, 15, 43 and 71 of maintenance therapy. Corticosteroids were given to prevent chemical arachnoiditis. All patients developed bilateral papilloedema after the third or fourth dose of liposomal cytarabine, local side effects were observed in two patients. Under prolonged dexamethasone therapy, side effects resolved completely. As reversible neuroophthalmological side effects caused by intrathecal liposomal cytarabine can also be observed under low-dose maintenance therapy in patients with CNS negative AML, it should be used with caution in children and adolescents.

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Authors and Affiliations

  1. Division of Paediatric Haematology and Oncology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 30, A-8036, Graz, Austria

    Constanze Sommer, Herwig Lackner, Martin Benesch, Petra Sovinz, Wolfgang Schwinger, Andrea Moser & Christian Urban

  2. Division of Neuroophthalmology, Department of Ophthalmology, Medical University of Graz, Auenbruggerplatz 30, Graz, A-8036, Austria

    Jutta Bergloeff & Anna Gruber

Authors
  1. Constanze Sommer
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  2. Herwig Lackner
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  3. Martin Benesch
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  4. Petra Sovinz
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  5. Wolfgang Schwinger
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  6. Andrea Moser
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  7. Jutta Bergloeff
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  8. Anna Gruber
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  9. Christian Urban
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Correspondence to Constanze Sommer.

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Sommer, C., Lackner, H., Benesch, M. et al. Neuroophthalmological side effects following intrathecal administration of liposomal cytarabine for central nervous system prophylaxis in three adolescents with acute myeloid leukaemia. Ann Hematol 87, 887–890 (2008). https://doi.org/10.1007/s00277-008-0521-9

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  • DOI: https://doi.org/10.1007/s00277-008-0521-9

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