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Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation

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Abstract

Purpose

The nonthermal irreversible electroporation (NTIRE) is a novel nonthermal tissue ablation technique by local application of high-voltage current within microseconds leading to a delayed apoptosis. The purpose of this experimental study was the first angiographic evaluation of the acute damage of renal vascular structure in NTIRE.

Methods

Results of conventional dynamic digital substraction angiography (DSA) and visualization of the terminal vascular bed of renal parenchyma by high-resolution X-ray in mammography technique were evaluated before, during, and after NTIRE of three isolated perfused porcine ex vivo kidneys.

Results

In the dedicated investigation, no acute vascular destruction of the renal parenchyma and no dysfunction of the kidney perfusion model were observed during or after NTIRE. Conspicuous were concentric wave-like fluctuations of the DSA contrast agent simultaneous to the NTIRE pulses resulting from NTIRE pulse shock wave.

Conclusion

The NTIRE offers an ablation method with no acute collateral vascular damage in angiographic evaluation.

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Conflict of interest

The authors declare that they have no conflicts of interest. This study was performed independently of the manufacturer of the devices used.

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Authors and Affiliations

  1. Department of Urology, University of Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Germany

    Johann Jakob Wendler, Simon Blaschke, Markus Porsch, Andreas Janitzky, Matthias Ulrich & Uwe-Bernd Liehr

  2. Department of Radiology and Nuclear Medicine, University of Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Germany

    Maciej Pech, Oliver Dudeck & Jens Ricke

Authors
  1. Johann Jakob Wendler
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  2. Maciej Pech
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  3. Simon Blaschke
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  4. Markus Porsch
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  5. Andreas Janitzky
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  6. Matthias Ulrich
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  7. Oliver Dudeck
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  8. Jens Ricke
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  9. Uwe-Bernd Liehr
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Corresponding author

Correspondence to Johann Jakob Wendler.

Additional information

Johann Jakob Wendler and Maciej Pech are contributed equally to this study.

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Wendler, J.J., Pech, M., Blaschke, S. et al. Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation. Cardiovasc Intervent Radiol 35, 383–390 (2012). https://doi.org/10.1007/s00270-011-0187-x

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  • DOI: https://doi.org/10.1007/s00270-011-0187-x

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