Abstract
Background
Advanced studies on adipose tissue have established that subcutaneous adipose tissue acts as an endocrine organ to help maintain homeostasis. Based on this information, many plastic surgeons have evaluated the metabolic effects of liposuction because liposuction is the most common surgical procedure in plastic surgery. Liposuction removes a substantial amount of subcutaneous fat from a specific area of the body. Mammoplasty is another procedure that removes a large amount of subcutaneous fat. In this study, the metabolic effects of reduction mammoplasty were evaluated with hemogram, blood glucose, lipid profile, insulin, and insulin resistance tests before and after surgery.
Methods
The study involved 35 patients who underwent reduction mammoplasty between January 2006 and June 2009. All the patients were evaluated with physical examination and their history, height, and weight were obtained. Venous blood samples were collected before, 4 h after, and 3 months after the surgical procedure to evaluate hemogram, blood glucose, insulin, and lipid profiles. The HOMA scores of the patients were calculated. Inferiorly based dermal pedicle, central pedicle, and free nipple graft techniques were used in the operations and all excision materials were sent for histopathological examination.
Results
The mean age of the patients was 39.6 ± 11.6 years. The mean excision volume was 2249 ± 1001 g. Body mass indexes were not significantly different before and 3 months after the surgery (p > 0.05). Blood glucose, LDL, HDL, triglyceride, total cholesterol, hemoglobin, and hematocrit values before and 4 h after the surgery were also different (p < 0.05). However, comparisons with the 3-month postoperative test results revealed no statistically significant differences (p > 0.05) and comparisons of all the measurements showed that insulin levels and HOMA scores were not significantly different (p > 0.05).
Conclusion
The results of the present study showed that reduction mammoplasty operations do not have any positive effects on blood insulin, glucose profile, lipid profile, and body mass index 3 months after the surgery.
Similar content being viewed by others
References
Psillakis JM, Cardoso de Oliveira M (1990) History of reduction mammoplasty. In: Goldwyn RM (ed) Reduction mammoplasty, 1st edn. Little, Brown, Boston, pp 1–15
Cruz-Korchin N, Korchin L, Gonzales-Kealan C, Climent C, Morales I (2002) Macromastia: how much of it is fat? Plast Reconstr Surg 109:64–68
Emral R (2006) Adiponectin and other cytokines. Türk Klin J Med Sci 26:409–420
Hong YG, Kim HT, Seo SW, Chang CH, Rhee EJ, Lee WY (2006) Impact of large volume liposuction on serum lipids in orientals: A pilot study. Aesthetic Plast Surg 30:327–332
Guigliano G, Nicoletti G, Grella E, Guigliano F, Esposito K, Scuderi N et al (2004) Effect of liposuction on insulin resistance and vascular inflammatory markers in obese woman. Br J Plast Surg 57:190–194
Robles Cervantes JA, Yanez-Diaz S, Cordenas Camarena L (2004) Modification of insulin, glucose and cholesterol in nonobese woman undergoing liposuction. Is liposuction metabolically safe? Ann Plast Surg 52:64–67
Gonzales-Ortiz M, Robles-Cervantes JA, Cordenas Camarena L, Bustos-Saldana R, Martinez-Abundis E (2002) The effects of surgically removing subcutaneous fat on the metabolic profile and insulin sensitivity in obese women after large volume liposuction treatment. Horm Metab Res 34:446–449
Rizzo MR, Paolisso G, Grella R, Barbieri M, Grella E et al (2005) Is dermolipectomy effective in improving insulin action and lowering inflammatory markers in obese woman? Clin Endocrinol 63:253–258
Klein S, Fontana L, Young L, Coggan A, Kilo C, Patterson BW et al (2004) Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Eng J Med 350:2549–2557
Matthews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419
Blomqvist L, Eriksson A, Brandberg Y (2000) Reduction mammoplasty provides long term improvement in health status and quality of life. Plast Reconstr Surg 106(5):991–997
Chao JD, Memmel HC, Redding JF, Egan L, Odom LC, Casas LA (2002) Reduction mammoplasty is a functional operation, improving quality of life in symptomatic women: a prospective single center breast reduction outcome study. Plast Reconstr Surg 110(7):1644–1652
Jones SA, Bain JR (2001) Review of data describing outcomes that are used to assess changes in quality of life after reduction mammoplasty. Plast Reconstr Surg 108(1):62–67
Benditte-Klepetko H, Leisser V, Paternostro-Sluga T, Rakos M, Trattnig S, Helbich T, Schemper M, Deutinger M (2007) Hypertrophy of the breast: a problem of beauty or health? J Women Health (Larchmt) 16(7):1062–1069
Gonzalez F, Walton RL, Shafer B, Matory WE Jr, Barah GL (1993) Reduction mammoplasty improves symptoms of macromastia. Plast Reconstr Surg 91:1270–1276
Mizgala CL, Mackenzie KM (2000) Breast reduction outcome study. Ann Plast Surg 44(2):125–133 discussion 133-134
Brown DM, Young VL (1993) Reduction mammoplasty for macromastia. Aesthetic Plast Surg 17:211–223
Pernia LR, Ronel DN, Leeper JD, Miller HL (2000) Carpal tunnel syndrome in women undergoing reduction mammoplasty. Plast Reconstr Surg 105:1314–1319
Rinomhota AS, Bulugahapitiya DUS, French SJ, Caddy CM, Griffiths RW et al (2008) Women gain weight and fat mass despite lipectomy at abdominoplasty and breast reduction. Eur J Endocrinol 158:349–352
Bailey JW, Anderson DB (1974) Rate of fat compensation and growth efficiency of lipectomized Sprague-Dawley rats. J Nutr 110:1785–1792
Chlouverakis C, Hojnicki D (1974) Lipectomy in obese hyperglycemic mice (ob/ob). Metabolism 23(2):133–137
Forger NG, Dark J, Zucker I (1986) Recovery of white adipose tissue after lipectomy in female ground squirrels. Can J Zool 64:128–131
Hausman DB, Lu J, Ryan DH, Flatt WP, Harris Ruth BS (2004) Compensatory growth of adipose tissue after partial lipectomy: involvement of serum factors. Exp Biol Med 229:512–520
Conflict of interest
The authors declare that they have no conflicts of interest to disclose.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sarıcı, M., Erol Demirseren, M., Durgun, M. et al. Effects of Reduction Mammoplasty on Metabolic Profile and Body Weight. Aesth Plast Surg 35, 995–999 (2011). https://doi.org/10.1007/s00266-011-9719-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00266-011-9719-7