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Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients

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Abstract

The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease. Adults (n = 168) with Kashin-Beck disease were randomised in clusters to receive six week courses of celecoxib 200 mg once daily, meloxicam 7.5 mg once daily or paracetamol 300 mg three times daily. Efficacy assessments included overall joint pain intensity and Western Ontario and McMaster Universities Osteoarthritis Index subscales; tolerability was evaluated by adverse event and physician reporting. Celecoxib and meloxicam were efficacious in relieving pain and improving stiffness, but unable to improve physical function after six weeks. Paracetamol was efficacious in relieving pain, but unable to improve morning stiffness and physical function after six weeks. Celecoxib and meloxicam provide predictable and sustained relief from pain and stiffness. Paracetamol can relieve the pain. None of the treatments improved impaired physical function in Kashin-Beck disease.

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Acknowledgements

The authors gratefully acknowledge the contribution made by Bing Li (secretary).

Disclosures

The authors declare that they have no competing interests.

Author information

Authors and Affiliations

  1. Department of Immunology and Rheumatology, West China Hospital, West China Medical School, Sichuan University, No. 17, Section 3, Southern Renmin Road, Chengdu, 610041, People’s Republic of China

    Rui Luo, Gang Liu, Wei Liu, Qibing Xie & Xin Ma

  2. Rheumatology Research Unit, State Key Laboratory, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China

    Gang Liu

  3. Department of Osteology, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China

    Fuxing Pei, Zongke Zhou, Jian Li, Bin Shen & Pengde Kang

Authors
  1. Rui Luo
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  2. Gang Liu
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  3. Wei Liu
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  4. Fuxing Pei
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  5. Zongke Zhou
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  6. Jian Li
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  7. Bin Shen
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  8. Pengde Kang
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  9. Qibing Xie
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  10. Xin Ma
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Corresponding author

Correspondence to Gang Liu.

Additional information

This study was partially supported by a grant from NSFC (Natural Science support project Item of China) 2007BA125B04 to Dr. Fuxing Pei ChiCTR-TCR-000000395.

Appendix

Appendix

Investigators

In the Medical College of Sichuan University, West China Hospital: Gang Liu, Luo Rui, Wei Liu, Yongtao Cheng, Dan Hu, Jiangang Wang, Li Li, Xin Ma, (rheumatologist), Fuxing Pei, Zongke Zhou, Jian Li, Bin Shen, Pengde Kang (orthopaedist); in the North Sichuan Medical College: JianPing Liu (rheumatologist); in the People’s Hospital of Sichuan province: JIanxin Zhu, Liuyi Tang, Chongxin Huang (orthopaedist); in the Chengdu Medical University of Chinese Medicine: Qun Gao (orthopaedist).

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Luo, R., Liu, G., Liu, W. et al. Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients. International Orthopaedics (SICOT) 35, 1409–1414 (2011). https://doi.org/10.1007/s00264-010-1062-0

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  • DOI: https://doi.org/10.1007/s00264-010-1062-0

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