Abstract
Numerous pediatric conditions result in hepatic fibrosis. As treatments develop for the underlying disorders, a non-invasive assessment of liver fibrosis would be beneficial as an adjunct or possible replacement for the traditional gold standard, liver biopsy. Magnetic resonance elastography is a noninvasive imaging technique that has been used successfully in adults for identification and assessment of liver fibrosis. This review describes the basic principles of MR elastography as well as the technical aspects specific to children. Clinical pediatric applications, limitations and areas for future research are described.
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References
Bonekamp S, Kamel I, Solga S et al (2009) Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately? J Hepatol 50:17–35
Yin M, Chen J, Glaser K et al (2009) Abdominal magnetic resonance elastography. Top Magn Reson Imaging 20:79–87
Mariappan YK, Glaser KJ, Ehman RL (2010) Magnetic resonance elastography: a review. Clin Anat 23:497–511
Yin M, Talwalkar JA, Glaser KJ et al (2007) Assessment of hepatic fibrosis with magnetic resonance elastography. Clin Gastroenterol Hepatol 5:1207–1213
Nobili V, Monti L, Alisi A et al (2011) Transient elastography for assessment of fibrosis in paediatric liver disease. Pediatr Radiol 41(10):1232–1238
Glaser KJ, Felmlee JP, Manduca A et al (2006) Stiffness-weighted magnetic resonance imaging. Magn Reson Med 55:59–67
Yin M, Talwalkar JA, Glaser KJ et al (2011) Dynamic post-prandial hepatic stiffness augmentation assessed with MR elastography in patients with chronic liver disease. AJR 197:64–70
Potter C, Hogan MJ, Henry-Kendjorsky K et al (2011) Safety of pediatric liver biopsy performed by interventional radiologists. J Pediatr Gastroenterol Nutr 53:202–206
Asbach P, Klatt D, Schlosser B et al (2010) Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography. Radiology 257:80–86
Huwart L, Sempoux C, Vicaut E et al (2008) Magnetic resonance elastography for the noninvasive staging of liver fibrosis. Clin Gastroenterol Hepatol 135:32–40
Huwart L, Sempoux C, Salmeh N et al (2007) Liver fibrosis: noninvasive assessment with MR elastography versus aspartate aminotransferase-to-platelet ratio index. Radiology 245:458–466
Faria SC, Ganesan K, Mwangi I et al (2009) MR imaging of liver fibrosis: current state of the art. Radiographics 29:1615–1635
Palmeri ML, Wang MH, Rouze NC et al (2011) Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease. J Hepatol 55:666–672
Menten R, Leonard A, Clapuyt P et al (2010) Transient elastography in patients with cystic fibrosis. Pediatr Radiol 40:1231–1235
Nobili V, Vizzutti F, Arena U et al (2008) Accuracy and reproducibility or transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 48:442–448
Chen J, Talwalkar JA, Meng Y et al (2011) Early detection of nonalcoholic steatohepatitis inpatients with nonalcoholic fatty liver disease by using MR elastography. Radiology 259:749–756
Talwalkar JA, Meng Y, Venkatesh et al (2009) Feasibility of in vivo MR elastographic splenic stiffness measurements in the assessment of portal hypertension. AJR 193:122–127
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This work was supported by NIH grant EB001981.
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Binkovitz, L.A., El-Youssef, M., Glaser, K.J. et al. Pediatric MR elastography of hepatic fibrosis: principles, technique and early clinical experience. Pediatr Radiol 42, 402–409 (2012). https://doi.org/10.1007/s00247-011-2298-6
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DOI: https://doi.org/10.1007/s00247-011-2298-6