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Antiretroviral Therapy and Pregnancy: Effect on Cortical Bone Status of Human Immunodeficiency Virus–Infected Caucasian Women as Assessed by Quantitative Ultrasonography

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Abstract

Treatment with antiretroviral agents (ARVs) during pregnancy is important to prevent mother-to-child transmission of the human immunodeficiency virus (HIV), but their use has been associated with low bone mineral density in adult patients. Currently, there are no data regarding the bone status of HIV-infected women who received ARV during pregnancy. The aim of this study was to evaluate cortical bone status at delivery in a group of HIV-infected women who received ARV during pregnancy and to monitor the changes occurring during the first year postpartum. We studied 33 HIV-infected and 116 HIV-uninfected healthy Caucasian women within 4 days from delivery. Follow-up measurements were performed at 4 and 12 months postpartum in 17 HIV-infected and 55 healthy women. Cortical bone status was evaluated by quantitative ultrasonography at the mid-tibia, and bone measurements were expressed as the speed of sound (SOS). HIV-infected women after delivery had a median SOS of 3,985 (3,567–4,242) m/s, while the median SOS of healthy women was 4,025 (3,643–4,250) m/s. The difference was not significant (t = 0.39, P = 0.69). No significant differences were observed between ARV-exposed and control subjects at 4 and 12 months. Our data suggest that ARV during pregnancy and the first year after delivery does not affect negatively cortical bone status.

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Acknowledgments

This study was supported in part by Grant “Bando nazionale AIDS 2009” (number 40H1).

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Authors and Affiliations

  1. Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy

    Stefano Mora & Cecilia Diceglie

  2. Department of Pediatrics, L. Sacco Hospital, University of Milan, Milan, Italy

    Alessandra Viganò, Vania Giacomet, Valeria Manfredini, Sara Stucchi, Valentina Fabiano, Chiara Mameli, Sonia Coletto & Gian V. Zuccotti

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  1. Stefano Mora
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  2. Cecilia Diceglie
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  3. Alessandra Viganò
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  4. Vania Giacomet
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  5. Valeria Manfredini
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  6. Sara Stucchi
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  7. Valentina Fabiano
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  8. Chiara Mameli
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  9. Sonia Coletto
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  10. Gian V. Zuccotti
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Correspondence to Stefano Mora.

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The authors have stated that they have no conflict of interest.

Stefano Mora and Cecilia Diceglie contributed equally to this study.

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Mora, S., Diceglie, C., Viganò, A. et al. Antiretroviral Therapy and Pregnancy: Effect on Cortical Bone Status of Human Immunodeficiency Virus–Infected Caucasian Women as Assessed by Quantitative Ultrasonography. Calcif Tissue Int 92, 394–398 (2013). https://doi.org/10.1007/s00223-013-9696-8

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  • DOI: https://doi.org/10.1007/s00223-013-9696-8

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