Skip to main content
Log in

Role of Hormonal Changes in the Pathogenesis of Osteoporosis in Men

  • Published:
Calcified Tissue International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1
Figure 2

References

  1. EP Smith J Boyd GR Frank H Takahashi RM Cohen B Specker TC Williams DB Lubahn KS Korach (1994) ArticleTitleEstrogen resistance caused by a mutation in the estrogen-receptor gene in a man N Engl J Med 331 1056–1061 Occurrence Handle10.1056/NEJM199410203311604 Occurrence Handle1:CAS:528:DyaK2MXitFWjt78%3D Occurrence Handle8090165

    Article  CAS  PubMed  Google Scholar 

  2. A Morishima MM Grumbach ER Simpson C Fisher K Qin (1995) ArticleTitleAromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens J Clin Endocrinol Metab 80 3689–3698 Occurrence Handle10.1210/jc.80.12.3689 Occurrence Handle1:STN:280:BymD1MvktFw%3D Occurrence Handle8530621

    Article  CAS  PubMed  Google Scholar 

  3. C Carani K Qin M Simoni M Faustini-Fustini S Serpente J Boyd KS Korach ER Simpson (1997) ArticleTitleEffect of testosterone and estradiol in a man with aromatase deficiency N Engl J Med 337 91–95 Occurrence Handle10.1056/NEJM199707103370204 Occurrence Handle1:CAS:528:DyaK2sXkvVCrsr4%3D Occurrence Handle9211678

    Article  CAS  PubMed  Google Scholar 

  4. JP Bilezikian A Morishima J Bell MM Grumbach (1998) ArticleTitleIncreased bone mass as a result of estrogen therapy in a man with aromatase deficiency N Engl J Med 339 599–603 Occurrence Handle10.1056/NEJM199808273390905 Occurrence Handle1:STN:280:DyaK1cznt1Cmsw%3D%3D Occurrence Handle9718379

    Article  CAS  PubMed  Google Scholar 

  5. A Falahati-Nini BL Riggs EJ Atkinson WM O’Fallon R Eastell S Khosla (2000) ArticleTitleRelative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men J Clin Invest 106 1553–1560 Occurrence Handle1:CAS:528:DC%2BD3cXovFagur8%3D Occurrence Handle11120762

    CAS  PubMed  Google Scholar 

  6. P Taxel DG Kennedy PM Fall AK Willard JM Clive LG Raisz (2001) ArticleTitleThe effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men J Clin Endocrinol Metab 86 2869–2874 Occurrence Handle10.1210/jc.86.6.2869 Occurrence Handle1:CAS:528:DC%2BD3MXktlKhs7g%3D Occurrence Handle11397902

    Article  CAS  PubMed  Google Scholar 

  7. BZ Leder KM LeBlanc DA Schoenfeld R Eastell JS Finkelstein (2003) ArticleTitleDifferential effects of androgens and estrogens on bone turnover in normal men J Clin Endocrinol Metab 813 204–210 Occurrence Handle10.1210/jc.2002-021036

    Article  Google Scholar 

  8. RT Turner GK Wakley KS Hannon (1990) ArticleTitleDifferential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats J Orthop Res 8 612–617 Occurrence Handle1:CAS:528:DyaK3MXkt1ansLc%3D Occurrence Handle2355301

    CAS  PubMed  Google Scholar 

  9. S Khosla LJ Melton SuffixIII EJ Atkinson WM O’Fallon GG Klee BL Riggs (1998) ArticleTitleRelationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen J Clin Endocrinol Metab 83 2266–2274 Occurrence Handle10.1210/jc.83.7.2266 Occurrence Handle1:CAS:528:DyaK1cXksVSjtbo%3D Occurrence Handle9661593

    Article  CAS  PubMed  Google Scholar 

  10. CW Slemenda C Longcope L Zhou SL Hui M Peacock C Johnston (1997) ArticleTitleSex steroids and bone mass in older men: positive associations with serum estrogens and negative associations with androgens J Clin Invest 100 1755–1759 Occurrence Handle1:CAS:528:DyaK2sXmsFeiu7w%3D Occurrence Handle9312174

    CAS  PubMed  Google Scholar 

  11. GA Greendale S Edelstein E Barrett-Connor (1997) ArticleTitleEndogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study J Bone Miner Res 12 1833–1843 Occurrence Handle1:CAS:528:DyaK2sXns1yjs78%3D Occurrence Handle9383688

    CAS  PubMed  Google Scholar 

  12. JR Center TV Nguyen PN Sambrook JA Eisman (1999) ArticleTitleHormonal and biochemical parameters in the determination of osteoporosis in elderly men J Clin Endocrinol Metab 84 3626–3635 Occurrence Handle10.1210/jc.84.10.3626 Occurrence Handle1:CAS:528:DyaK1MXms1OhtLY%3D Occurrence Handle10523006

    Article  CAS  PubMed  Google Scholar 

  13. B Ongphiphadhanakul R Rajatanavin S Chanprasertyothin N Piaseau L Chailurkit (1998) ArticleTitleSerum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males Clin Endocrinol 49 803–809 Occurrence Handle10.1046/j.1365-2265.1998.00631.x Occurrence Handle1:CAS:528:DyaK1MXkt1WjtA%3D%3D

    Article  CAS  Google Scholar 

  14. AW Beld ParticleVan den FH Jong Particlede DE Grobbee HAP Pols SWJ Lamberts (2000) ArticleTitleMeasures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men J Clin Endocrinol Metab 85 3276–3282 Occurrence Handle10.1210/jc.85.9.3276 Occurrence Handle10999822

    Article  PubMed  Google Scholar 

  15. S Amin Y Zhang CT Sawin SR Evans MT Hannan DP Kiel PWF Wilson DT Felson (2000) ArticleTitleAssociation of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study Ann Intern Med 133 951–963 Occurrence Handle1:STN:280:DC%2BD3M%2Fms1Khtg%3D%3D Occurrence Handle11119396

    CAS  PubMed  Google Scholar 

  16. P Szulc F Munoz B Claustrat P Garnero F Marchand (2001) ArticleTitleBioavailable estradiol may be an important determinant of osteoporosis in men: the MINOS study J Clin Endocrinol Metab 86 192–199 Occurrence Handle10.1210/jc.86.1.192 Occurrence Handle1:CAS:528:DC%2BD3MXhtVGnsL4%3D Occurrence Handle11232000

    Article  CAS  PubMed  Google Scholar 

  17. S Khosla LJ Melton SuffixIII EJ Atkinson WM O’Fallon (2001) ArticleTitleRelationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men J Clin Endocrinol Metab 86 3555–3561 Occurrence Handle10.1210/jc.86.8.3555 Occurrence Handle1:CAS:528:DC%2BD3MXlvFektrg%3D Occurrence Handle11502778

    Article  CAS  PubMed  Google Scholar 

  18. E Seeman (2002) ArticleTitlePathogenesis of bone fragility in women and men Lancet 359 1841–1850 Occurrence Handle10.1016/S0140-6736(02)08706-8 Occurrence Handle12044392

    Article  PubMed  Google Scholar 

  19. J Pfeilshifter C Scheidt-Nave G Leidig-Bruckner WW Woitge WF Blum C Wuster D Haack R Ziegler (1996) ArticleTitleRelationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women J Clin Endocrinol Metab 81 2534–2540 Occurrence Handle10.1210/jc.81.7.2534 Occurrence Handle1:CAS:528:DyaK28XktFaktrk%3D Occurrence Handle8675573

    Article  CAS  PubMed  Google Scholar 

  20. JC Crave H Lejeune C Brebant C Baret M Pugeat (1995) ArticleTitleDifferential effects of insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (HepG2) cells J Clin Endocrinol Metab 80 1283–1289 Occurrence Handle10.1210/jc.80.4.1283 Occurrence Handle1:CAS:528:DyaK2MXkvFejs70%3D Occurrence Handle7536204

    Article  CAS  PubMed  Google Scholar 

  21. TA Bateman RJ Zimmerman RA Ayers VL Ferguson SK Chapes SJ Simske (1998) ArticleTitleHistomorphometric, physical, and mechanical effects of spaceflight and insulin-like growth factor-I on rat long bones Bone 23 527–535 Occurrence Handle10.1016/S8756-3282(98)00135-5 Occurrence Handle1:CAS:528:DyaK1MXlslCk Occurrence Handle9855461

    Article  CAS  PubMed  Google Scholar 

  22. P Gillberg AG Johansson . Ljunghall (1999) ArticleTitleDecreased estradiol levels and free androgen index and elevated sex hormone-binding globulin levels in male idiopathic osteoporosis Calcif Tissue Int 64 209–213 Occurrence Handle10.1007/s002239900604 Occurrence Handle1:CAS:528:DyaK1MXhs1ymurw%3D Occurrence Handle10024377

    Article  CAS  PubMed  Google Scholar 

  23. E Legrand C Hedde Y Gallois I Degasne F Boux Casson Particlede E Mathieu MF Basle D Chappard M Audran (2001) ArticleTitleOsteoporosis in men: Apotential role for the sex hormone binding globulin Bone 29 90–95 Occurrence Handle10.1016/S8756-3282(01)00478-1 Occurrence Handle1:CAS:528:DC%2BD3MXltlOisrc%3D Occurrence Handle11472897

    Article  CAS  PubMed  Google Scholar 

  24. SF Evans MWJ Davie (2002) ArticleTitleLow body size and elevated sex-hormone binding globulin distinguish men with idiopathic vertebral fracture Calcif Tissue Int 70 9–15 Occurrence Handle10.1007/s00223-001-2018-6 Occurrence Handle1:CAS:528:DC%2BD38XjvFSjtbg%3D Occurrence Handle11907702

    Article  CAS  PubMed  Google Scholar 

  25. CG Carlsen TH Soerensen EF Eriksen (2000) ArticleTitlePrevalence of low serum estradiol levels in male osteoporosis Osteoporosis Int 11 697–701 Occurrence Handle10.1007/s001980070068 Occurrence Handle1:CAS:528:DC%2BD3cXnsVegtbo%3D

    Article  CAS  Google Scholar 

  26. ES Kurland CJ Rosen F Cosman D McMahon F Chan E Shane R Lindsay D Dempster JP Bilezikian (1997) ArticleTitleInsulin-like growth factor-I in men with idiopathic osteoporosis J Clin Endocrinol Metab 82 2799–2805 Occurrence Handle10.1210/jc.82.9.2799 Occurrence Handle1:CAS:528:DyaK2sXlvFems7g%3D Occurrence Handle9284699

    Article  CAS  PubMed  Google Scholar 

  27. ES Kurland FKW Chan CJ Rosen JP Bilezekian (1998) ArticleTitleNormal growth hormone secretory reserve in men with idiopathic osteoporosis and reduced circulating levels of insulin-like growth factor-I J Clin Endocrinol Metab 83 2576–2579 Occurrence Handle10.1210/jc.83.7.2576 Occurrence Handle1:CAS:528:DyaK1cXksVSisLY%3D

    Article  CAS  Google Scholar 

  28. CJ Rosen ES Kurland D Vereault RA Adler PJ Rackoff WY Craig S Witte J Rogers JP Bilezikian (1998) ArticleTitleAssociation between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density J Clin Endocrinol Metab 83 2286–2290 Occurrence Handle10.1210/jc.83.7.2286 Occurrence Handle1:CAS:528:DyaK1cXksVSjtbk%3D Occurrence Handle9661596

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Khosla.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khosla, S. Role of Hormonal Changes in the Pathogenesis of Osteoporosis in Men. Calcif Tissue Int 75, 110–113 (2004). https://doi.org/10.1007/s00223-004-0290-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00223-004-0290-y

Keywords

Navigation