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The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site

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Abstract

Incubation of both sarin and soman with human plasma has shown that binding occurs to a tyrosine residue. Similar binding occurs when sarin and soman are incubated with human serum albumin. This binding may provide an important biological marker, which retains full structural information concerning the identity of the agent, in cases of allegations of chemical warfare use.

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Authors and Affiliations

  1. DERA, CBD Porton Down, Salisbury, Wilts, SP4 0JQ, UK e-mail: jmharrison@dera.gov.uk Tel.: 0044 1980 613565; Fax: 0044 1980 613371, , , , , , GB

    Robin M. Black, John M. Harrison & Robert W. Read

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  1. Robin M. Black
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  2. John M. Harrison
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  3. Robert W. Read
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Received: 16 November 1998 / Accepted: 12 January 1999

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Black, R., Harrison, J. & Read, R. The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site. Arch Toxicol 73, 123–126 (1999). https://doi.org/10.1007/s002040050596

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  • DOI: https://doi.org/10.1007/s002040050596

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