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Barrierefunktion der gesunden Haut

Morphologische und funktionelle Aspekte der Hautbarriere

The barrier function of normal skin

Morphologic and functional aspects of the skin barrier

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Abbreviations

AD:

Atopische Dermatitis (Neurodermitis)

AMPs:

Antimikrobielle Peptide

CDs:

Corneodesmosomen

CE:

Cornified envelope

CLE:

Corneocyte lipid envelope

FLG:

Filaggrin

KRT:

Keratin

LBs:

Lamellar bodies (Odland-Körperchen)

LEKTI:

Lymphoepithelial Kazal type inhibitor

NMF:

Natural moisturizing factor

PAMPs:

Pathogen associated molecular patterns

SC:

Stratum corneum (Hornschicht)

SG:

Stratum granulosum (Körnerzellschicht)

SKALP:

Skin-derived Antileukoproteinase (Elafin)

TEWL:

Transepidermaler Wasserverlust

TGM1:

Transglutaminase 1

TJs:

Tight junctions (Schlussleisten)

t-UCA:

Trans-Urokansäure

Literatur

  1. Elias PM (2005) Stratum corneum defensive functions: an integrated view. J Invest Dermatol 125:183–200

    CAS  PubMed  Google Scholar 

  2. Proksch E, Brandner JM, Jensen JM (2008) The skin: an indispensable barrier. Exp Dermatol 17:1063–1072

    Article  PubMed  Google Scholar 

  3. Elias PM (1981) Lipids and the epidermal permeability barrier. Arch Dermatol Res 270:95–117

    Article  CAS  PubMed  Google Scholar 

  4. Schmuth M et al (2013) Inherited ichthyoses/generalized Mendelian disorders of cornification. Eur J Hum Genet 21:123–133

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Eckhart L et al (2013) Cell death by cornification. Biochim Biophys Acta 1833:3471–3480

    Article  CAS  PubMed  Google Scholar 

  6. Elias PM et al (2013) Formation and functions of the corneocyte lipid envelope (CLE). Biochim Biophys Acta [Epub ahead of print]

  7. Sandilands A et al (2007) Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet 39:650–654

    Article  CAS  PubMed  Google Scholar 

  8. Kezic S et al (2011) Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy 66:934–940

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Iwai I et al (2012) The human skin barrier is organized as stacked bilayers of fully extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety. J Invest Dermatol 132:2215–2225

    Article  CAS  PubMed  Google Scholar 

  10. Janssens M et al (2011) Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema. J Invest Dermatol 131:2136–2138

    Article  CAS  PubMed  Google Scholar 

  11. Jensen et al (2004) Impaired sphingomyelinase activity and epidermal differentiation in atopisc dermatitis. J Invest Dermatol 122:1423–1431

    Article  CAS  PubMed  Google Scholar 

  12. Kubo A, Nagao K, Amagai M (2012) Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest 122:440–447

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Hadj-Rabia S et al (2004) Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. Gastroenterology 127:1386–1390

    Article  CAS  PubMed  Google Scholar 

  14. Gruber R et al (2011) Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Am J Pathol 178:2252–2263

    Article  PubMed Central  PubMed  Google Scholar 

  15. De Benedetto A et al (2011) Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol 127:773–786

    Article  Google Scholar 

  16. Zasloff M (2002) Antimicrobial peptides in health and disease. N Engl J Med 347(15):1199–1200

    Article  PubMed  Google Scholar 

  17. Ong PY et al (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347(15):1151–1160

    Article  CAS  PubMed  Google Scholar 

  18. Aberg KM et al (2008) Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 128:917–925

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Schauber J, Gallo RL (2009) Antimicrobial peptides and the skin immune defense system. J Allergy Clin Immunol 124(3 Suppl 2):R13–R18

    Article  CAS  PubMed  Google Scholar 

  20. Ogawa F et al (2006) The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation. J Invest Dermatol 126:1128–1134

    Article  CAS  PubMed  Google Scholar 

  21. Bikle DD, Xie Z, Tu CL (2012) Calcium regulation of keratinocyte differentiation. Expert Rev Endocrinol Metab 7:461–472

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Segre JA (2006) Epidermal barrier formation and recovery in skin disorders. J Clin Invest 116:1150–1158

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Interessenkonflikt

R. Gruber und M. Schmuth geben an, dass kein Interessenkonflikt besteht.

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Gruber, R., Schmuth, M. Barrierefunktion der gesunden Haut. Hautarzt 65, 234–240 (2014). https://doi.org/10.1007/s00105-013-2691-1

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  • DOI: https://doi.org/10.1007/s00105-013-2691-1

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