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Dermatoendokrinologie

Hautalterung

Dermatoendocrinology

Skin Aging

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Zusammenfassung

Hormone und deren Inbalancen haben signifikante Auswirkungen auf die Morphologie und die Physiologie der Haut und beeinflussen verschiedene Hautfunktionen, u. a. die Wundheilung und die Lipogenese. Mit zunehmendem Alter nimmt die Konzentration von wichtigen zirkulierenden Hormonen, darunter Wachstumsfaktoren und Sexualsteroide, kontinuierlich ab. Infolgedessen werden physiologische Prozesse der Haut negativ beeinflusst, und es kann zur Entwicklung verschiedener alterungsassoziierter Erkrankungen kommen. Das Verständnis derartiger fundamentaler Zusammenhänge wird im Hinblick auf die Verschiebung der Alterspyramide, bei Erhöhung der Anzahl der über 80-jährigen Menschen größte Bedeutung erlangen und ist ebenfalls bei der Krankheitsprävention entscheidend.

Abstract

Hormones and their imbalances have significant effects on the morphology and physiology of the skin and influence various skin functions, especially wound healing and lipogenesis. With increasing age, the concentrations of important circulating hormones, including growth hormone and sex-related steroids, decrease continuously. As a result, physiologic processes are negatively influenced and various age-associated disorders may develop. As the population aged 80 and over is expected to rise in the next decades, the understanding of the molecular mechanisms accompanying skin aging and disease prevention will become even more important and play a role in preventing disease.

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  1. Klinik für Dermatologie, Venerologie und Allergologie/Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland

    E. Makrantonaki & C.C. Zouboulis

  2. Laboratorium für Biogerontologie, Dermato-Pharmakologie und Dermato-Endokrinologie, Institut für Klinische Pharmakologie und Toxikologie, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Deutschland

    E. Makrantonaki

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  2. C.C. Zouboulis
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Makrantonaki, E., Zouboulis, C. Dermatoendokrinologie. Hautarzt 61, 505–510 (2010). https://doi.org/10.1007/s00105-009-1889-8

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