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Besonderheiten der Haut des Neugeborenen und jungen Säuglings

Special features of the skin in newborns and infants

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Zusammenfassung

Die genaue Kenntnis der Besonderheiten kindlicher und insbesondere neonataler Haut ist die Grundvoraussetzung für eine adäquate pädiatrisch-dermatologische Versorgung dieser Altersgruppe. Die Haut des Neugeborenen übernimmt unmittelbar postpartal vitale Aufgaben des Wasser- und Elektrolythaushaltes, der Thermoregulation sowie der innaten und adaptiven Immunabwehr. Die Haut Frühgeborener bedarf aufgrund ihrer funktionellen und strukturellen Unreife in den ersten Lebenswochen einer besonderen Pflege. Reife Neugeborene zeigen zusätzlich benigne, transiente Hauterscheinungen, die von behandlungsbedürftigen und potenziell lebensbedrohlichen Erkrankungen unterschieden werden müssen.

Abstract

Detailed knowledge of the special features of neonatal and infant skin is a prerequisite for adequate skin care in this age group. Immediately postpartum, the newborn baby’s skin assumes vital functions regarding water and electrolyte homeostasis and thermoregulation, as well as innate and adaptive host defense. Due to its functional and structural immaturity, premature skin requires special care. Mature neonates demonstrate benign, transient skin lesions that do not require specific therapy but have to be distinguished from serious and potentially life-threatening illnesses.

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Notes

  1. g=Gramm H2O, m2=Verdunstungsfläche, h=Stunde.

Literatur

  1. Agren J, Zelenin S, Hakansson M, Eklöf AC (2003) Transepidermal water loss in developing rats: role of aquaporins in the immature skin. Pediatr Res 53:558–565

    Article  PubMed  Google Scholar 

  2. Akinbi HAT, Narendran V, Kun Pass A et al. (2004) Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstetr Gynecol 191:2090–2096

    Article  Google Scholar 

  3. Braff MH, Bardan A, Nizet V, Gallo RL (2005) Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol 125:9–13

    Article  PubMed  Google Scholar 

  4. Cartlidge P (2000) The epidermal barrier. Semin Neonatol 5:273–280

    Article  PubMed  Google Scholar 

  5. Chiou YB, Blume-Peytavi U (2004) Stratum corneum maturation. Skin Pharmacol Physiol 17:57–66

    Article  PubMed  Google Scholar 

  6. Conner JM, Soll RF, Edwards WH (2004) Topical ointment for preventing infection in preterm infants. Cochrane Database Syst Rev 1:CD001150

    PubMed  Google Scholar 

  7. Darmstadt GL, Saha SK, Nawshad Uddin Ahmed ASM et al. (2005) Effect of topical treatment with skin barrier-enhancing emollients on nosocomial infections in preterm infants in Bangladesh: a randomized controlled trial. Lancet 365:1039–1045

    PubMed  Google Scholar 

  8. Dorschner RA, Lin KH, Murakami M, Gallo RL (2003) Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response. Pediatr Res 53:566–572

    Article  PubMed  Google Scholar 

  9. Eady R, Goldsmith L, Dahl M (2003) Embryogenesis of the skin. In: Schachner L, Hansen RC (eds) Pediatric dermatology. Mosby, Edinburgh London New York, pp 3–13

  10. Grünhagen DJ, De Boer MGJ, De Beaufort AJ, Walther FJ (2002) Transepidermal water loss during halogen spotlight phototherapy in preterm infants. Pediatr Res 51:402–405

    PubMed  Google Scholar 

  11. Hoath SB, Narendran V (2000) Adhesives and emollients in the preterm infant. Semin Neonatol 5:289–296

    Article  PubMed  Google Scholar 

  12. Höger PH (2004) Physiologie der Haut des Neugeborenen und jungen Säuglings. Kinder Jugendmedizin 4:73–79

    Google Scholar 

  13. Höger PH (2005) Besonderheiten der Pharmakokinetik im Kindesalter. In: Plewig G, Kaudewitz P, Sander CA (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie. Springer, Berlin Heidelberg New York Tokyo, pp 492–496

  14. Hoeger PH, Enzmann CC (2002) Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Ped Dermatol 19:256–262

    Article  Google Scholar 

  15. Hoeger PH, Yates RW, Harper JI (1998) Neonatal erythroderma: differential diagnosis and management of the „red baby“. Arch Dis Child 79:186–191

    PubMed  Google Scholar 

  16. Hoeger PH, Schreiner V, Klaassen IA et al. (2002) Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern in vernix and fetal skin. Br J Dermatol 146:194–201

    Article  PubMed  Google Scholar 

  17. Jain A, Rutter N, Cartlidge PH (2000) Influence of antenatal steroids and sex on maturation of the epidermal barrier in the preterm infant. Arch Dis Child Fetal Neonatal Ed 83:F112–F116

    Article  PubMed  Google Scholar 

  18. Kaufman D, Fairchild KD (2004) Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin Microbiol Rev 17:638–680

    Article  PubMed  Google Scholar 

  19. Liu C, Feng J, Qu R, et al. (2005) Epidemiologic study of the predisposing factors in erythema toxicum neonatorum. Dermatology 210:269–272

    Article  PubMed  Google Scholar 

  20. Loden M, Andersson AC, Anderson C et al. (2002) A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients. Acta Derm Venereol 82:45–47

    Article  PubMed  Google Scholar 

  21. Marchini G, Ulfgren AK, Lore K et al. (2001) Erythema toxicum neonatorum: an immunohistochemical analysis. Pediatr Dermatol 18:177–187

    Article  PubMed  Google Scholar 

  22. McCall EM, Alderdice FA, Halliday HL et al. (2005) Interventions to prevent hypothermia at birth in preterm and/or low birthweight babies. Cochrane Database Syst Rev 1:CD004210

    PubMed  Google Scholar 

  23. McIntyre J, Choonara I (2004) Drug toxicity in the neonate. Biol Neonate 86:218–221

    Article  PubMed  Google Scholar 

  24. Pickens WL, Warner RR, Boissy YL et al. (2000) Characterization of vernix caseosa: water content, morphology and elemental analysis. J Invest Dermatol 115:875–881

    Article  PubMed  Google Scholar 

  25. Rayner W (1886) Cyanosis in newly born children caused by aniline marking ink. Br Med J I:294

    Google Scholar 

  26. Rutter N (2000) Clinical consequences of an immature barrier. Semin Neonatol 5:281–287

    Article  PubMed  Google Scholar 

  27. Rutter N (2000) The dermis. Semin Neonatol 5:297–302

    Article  PubMed  Google Scholar 

  28. Schlüter H, Wepf R, Moll I et al. (2004) Sealing the live part of the skin: the integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis. Eur J Cell Biol 83:655–665

    Article  PubMed  Google Scholar 

  29. Sedin G (2004) To avoid heat loss in very preterm infants. J Pediatr 145:720–722

    Article  PubMed  Google Scholar 

  30. Sekkat N, Kalia YN, Guy RH (2004) Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates. Pharm Res 21:1390–1397

    Article  PubMed  Google Scholar 

  31. Verbov J (2000) Common skin conditions in the newborn. Semin Neonatol 5:303–310

    Article  PubMed  Google Scholar 

  32. Visscher MO, Narendran V, Pickens WL, Laruffa A et al. (2005) Vernix caseosa in neonatal adaptation. J Perinatol 25:440–446

    Article  PubMed  Google Scholar 

  33. Yosipovitch G, Maayan-Metzger A, Merlob P, Sirota L (2000) Skin barrier properties in different areas in neonates. Pediatrics 106:105–108

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Kinderklinik und Klinik für Dermatologie und Allergologie, Universitätsklinikum Aachen

    H. Ott

  2. Abteilungen Allgemeine Pädiatrie und Pädiatrische Dermatologie, Kath. Kinderkrankenhaus Wilhelmstift, Hamburg

    P. H. Höger

  3. Kath. Kinderkrankenhaus Wilhelmstift, Liliencronstraße 130, 22149 , Hamburg

    P. H. Höger

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  1. H. Ott
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  2. P. H. Höger
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Correspondence to P. H. Höger.

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Ott, H., Höger, P.H. Besonderheiten der Haut des Neugeborenen und jungen Säuglings. Hautarzt 56, 905–914 (2005). https://doi.org/10.1007/s00105-005-1013-7

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  • DOI: https://doi.org/10.1007/s00105-005-1013-7

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