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Antimikrobielle Peptide

Eine Perspektive in der Therapie chronischer Wunden?

Antimicrobial peptides

A perspective for the treatment of chronic wounds?

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Zusammenfassung

Humane antimikrobielle Peptide spielen eine wesentliche Rolle in der Immunantwort verschiedener dermatologischer Krankheitsbilder wie der Akne der atopischen Dermatitis und der Psoriasis vulgaris. Auch die mukosale HIV-Protektion wird unter anderem über antimikrobielle Peptide vermittelt. In der Wundheilung zeigte sich, dass insbesondere humane β-Defensine und Cathelizidine durch ihre antimikrobielle und immunmodulierende Potenz wesentliche Einflussfaktoren modulieren können. So wird z. B. durch das Zusammenspiel verschiedener antimikrobieller Peptide und Wachstumsfaktoren die Neoangiogenese gefördert. Auch wenn aktuell weitere klinische Untersuchungen notwendig sind, um die exakten Wirkmechanismen von antimikrobiellen Peptiden in chronischen Wunden zu identifizieren, könnten antimikrobielle Peptide durch Förderung der endogenen Expression oder exogene Supplementierung in absehbarer Zukunft eine interessante Therapieoption in der Behandlung von Patienten mit chronischen Wunden darstellen.

Abstract

Human antimicrobial peptides play a substantial role in the immune response to various dermatological diseases, such as acne, atopic dermatitis and psoriasis vulgaris, and even mucosal HIV-protection is mediated inter alia by antimicrobial peptides. In wound healing, the antimicrobial and immune-modulating properties of, in particular, human defensins and cathelicidins can affect important controlling factors. For example, the interaction between different antimicrobial peptides and growth factors supports neoangiogenesis. Although further clinical investigations are necessary to identify the exact effects of antimicrobial peptides in chronic wounds, such peptides could be a promising therapeutic option in the near future for the treatment of patients with chronic wounds by promoting endogen expression or exogenous supplementation.

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Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen

    A. Körber, S. Grabbe &  J. Dissemond

  2. Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen

    J. Dissemond

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  1. A. Körber
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  2. S. Grabbe
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  3. J. Dissemond
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Correspondence to J. Dissemond.

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Körber, A., Grabbe, S. & Dissemond, J. Antimikrobielle Peptide. Hautarzt 56, 860–865 (2005). https://doi.org/10.1007/s00105-005-0915-8

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  • DOI: https://doi.org/10.1007/s00105-005-0915-8

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