Abstract.
Annexins constitute a family of structurally related calcium- and phospholipid-binding proteins whose molecular structure has been investigated in detail in the crystalline and membrane-bound form. Their polypeptide chain is folded into four or eight α-helical domains of similar structure with a central hydrophilic pore. Bound to phospholipid membranes, the four-domain arrangement of the annexin molecule is conserved. A peripheral binding mode has been well documented by electron microscopy and a variety of other techniques.
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Liemann, S., Huber, R. Three-dimensional structure of annexins. CMLS, Cell. mol. life sci. 53, 516–521 (1997). https://doi.org/10.1007/s000180050065
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DOI: https://doi.org/10.1007/s000180050065