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Peripheral regulation of food intake: New insights

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Abstract

Appetite is controlled by a complicated system with hunger and satiety signals interacting in complex pathways both peripherally and centrally. Insulin, leptin and ghrelin are key hormonal regulators of food intake. Ghrelin enhances appetite while leptin is a satiety signal. A novel peripheral regulator of food intake, peptide YY3–36, is released from the gastrointestinal tract postprandially. In this review old and new peripheral signals and their interaction in the control of food intake are briefly discussed.

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References

  1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402: 656–60.

    Article  CAS  PubMed  Google Scholar 

  2. Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000, 407: 908–13.

    Article  PubMed  Google Scholar 

  3. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000, 141: 4325–8.

    Article  CAS  PubMed  Google Scholar 

  4. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001, 409: 194–8.

    Article  CAS  PubMed  Google Scholar 

  5. Tamura H, Kamegai J, Shimizu T, Ishii S, Sugihara H, Oikawa S. Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology 2002, 143: 3268–75.

    Article  CAS  PubMed  Google Scholar 

  6. Shuto Y, Shibasaki T, Otagiri A, et al. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J Clin Invest 2002, 109: 1429–36.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001, 86: 5992.

    Article  CAS  PubMed  Google Scholar 

  8. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001, 50: 1714–9.

    Article  CAS  PubMed  Google Scholar 

  9. Tschöp M, Viswanath D, Weyer C, Tataranni PA, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001, 50: 707–9.

    Article  PubMed  Google Scholar 

  10. Broglio F, Arvat E, Benso A, et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 2001, 86: 5083.

    Article  CAS  PubMed  Google Scholar 

  11. Otto B, Cuntz U, Fruehauf E, et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001, 145: 669–73.

    Article  CAS  PubMed  Google Scholar 

  12. Ukkola O, Poykko S. Ghrelin, growth and obesity. Ann Med 2002, 34: 102–8.

    Article  CAS  PubMed  Google Scholar 

  13. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002, 346: 1623–30.

    Article  PubMed  Google Scholar 

  14. Johannsson G, Bengtsson BA. Growth hormone and the metabolic syndrome. J Endocrinol Invest 1999, 22: 41–6.

    CAS  PubMed  Google Scholar 

  15. Lindeman JH, Pijl H, Van Dielen FM, Lentjes EG, Van Leuven C, Kooistra T. Ghrelin and the Hyposomatotropism of Obesity. Obes Res 2002, 10: 1161–6.

    Article  CAS  PubMed  Google Scholar 

  16. Cummings DE, Clement K, Purnell JQ, et al. Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 2002, 8: 643–4.

    Article  CAS  PubMed  Google Scholar 

  17. Ishii S, Kamegai J, Tamura H, Shimizu T, Sugihara H, Oikawa S. Role of ghrelin in streptozotocin-induced diabetic hyperphagia. Endocrinology 2002, 143: 4934–7.

    Article  CAS  PubMed  Google Scholar 

  18. Havel PJ. Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med (Maywood) 2001, 226: 963–77.

    CAS  Google Scholar 

  19. Williams G, Bing C, Cai XJ, Harrold J.A, King PJ, Liu XH. The hypothalamus and the control of energy homeostasis. Different circuits, different purposes. Physiol Behav 2001, 74: 683–701.

    Article  CAS  PubMed  Google Scholar 

  20. Moran TH. Cholecystokinin and satiety: Current perspectives. Nutrition 2000, 16: 858–65.

    Article  CAS  PubMed  Google Scholar 

  21. Meier JJ, Gallwitz B, Schmidt WE, et al. Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives. Eur J Pharmacol 2002, 440: 269–79.

    Article  CAS  PubMed  Google Scholar 

  22. Djurhuus CB, Hansen TK, Gravholt C, et al. Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion. Horm Metab Res 2002, 34: 411–3.

    Article  CAS  PubMed  Google Scholar 

  23. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3–36) physiologically inhibits food intake. Nature 2002, 418: 650–4.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine and Biocenter Oulu, University of Oulu, Kajaanintie 50/P.O. Box 5000, Oulu, FIN-90014, Finland

    O. Ukkola MD, PhD

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  1. O. Ukkola MD, PhD
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Correspondence to O. Ukkola MD, PhD.

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Ukkola, O. Peripheral regulation of food intake: New insights. J Endocrinol Invest 27, 96–98 (2004). https://doi.org/10.1007/BF03350918

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  • DOI: https://doi.org/10.1007/BF03350918

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