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Association between a-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis

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Abstract

Linkage and association studies suggested the relationship between a-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. However, the currently available results were inconsistent. This study aimed to define quantitatively the association between salt-sensitivity and α-adducin Gly460Trp polymorphism in all published case-control studies. Publications from PubMed and other databases were retrieved. The major inclusion criteria were: (1) case-control design; (2) salt-sensitivity confirmed by sodium loading tests, and (3) the distribution of genotypes given in detail. Seven case-control studies fulfilled the inclusion criteria. In total they involved 820 subjects (454 salt-sensitive and 366 non-salt-sensitive). The meta-analysis shows that Gly460Trp polymorphism in general is not significantly associated with salt-sensitivity [OR (95%CI): 1.40 (0.96, 2.04),P = 0.08]. Subgroup analysis showed that the association is statistically significant in Asian people [OR (95%CI):1.33 (1.06, 1.69),P = 0.02] but not in Caucasian people [OR (95%CI):1.98 (0.57, 6.92),P = 0.28]. This indicates that blood pressure response to sodium varies between ethnical groups. More studies based on a larger population are required to evaluate further the role of a-adducin Gly460Trp polymorphism in salt-sensitive hypertension.

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Authors and Affiliations

  1. Department of Cardiology, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, China

    R. Wang

  2. Affiliated Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

    B. Zhong

  3. Tianjin University of TCM, Tianjin, China

    Y. Liu

  4. Baylor College of Medicine and The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    C. Wang

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  1. R. Wang
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  2. B. Zhong
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  3. Y. Liu
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  4. C. Wang
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Correspondence to R. Wang, B. Zhong or C. Wang.

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Wang, R., Zhong, B., Liu, Y. et al. Association between a-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis. J Appl Genet 51, 87–94 (2010). https://doi.org/10.1007/BF03195715

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  • DOI: https://doi.org/10.1007/BF03195715

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