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Altered GABAergic and glutamatergic transmission in audiogenic seizure-susceptible mice

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Abstract

The C57BL/10 SPS/sps mouse mutant are audiogenic seizure-susceptible. The enzymatic activities of glutamate decarboxylase (GAD), GABA aminotransferase (GABA-T), alanine aminotransferase (ALA-T), aspartate aminotransferase (ASP-T), and glutamate dehydrogenase (GDH) of whole brain supernatant are significantly reduced in these epileptic mice. GABA uptake is decreased in cortex, midbrain, and pons medulla. Previous studies showed the presence of two sodium-dependent GLU uptake systems in normal (SPS/SPS) mice. Glutamate Umax by System 1 is significantly decreased in these mice, whereas the Umax value for System 2 is significantly increased in the epileptic mice.

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Abbreviations

GABA:

gamma-aminobutyric acid

GLU:

l-glutamic acid

SPS/SPS:

normal mice

SPS/sps:

epileptic (audiogenic seizure-susceptible) mice

NMDA:

N-methyl-d-aspartate

EAA:

excitatory amino acids

GAD:

glutamate decarboxylase

GABA-T:

GABA aminotransferase

ALA-T:

alanine aminotransferase

ASP-T:

aspartate aminotransferase

GDH:

glutamate dehydrogenase

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Authors and Affiliations

  1. Department of Pharmacology, University of Puerto Rico, School of Medicine, PO Box 365067, 00936-5067, San Juan, Puerto Rico

    M. L. Cordero, J. G. Ortiz, G. Santiago, A. Negrón & J. A. Moreira

Authors
  1. M. L. Cordero
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  2. J. G. Ortiz
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  3. G. Santiago
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  4. A. Negrón
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  5. J. A. Moreira
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Cordero, M.L., Ortiz, J.G., Santiago, G. et al. Altered GABAergic and glutamatergic transmission in audiogenic seizure-susceptible mice. Mol Neurobiol 9, 253–258 (1994). https://doi.org/10.1007/BF02816124

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