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Lymphocyte glutathione peroxidase activity during exacerbations in multiple sclerosis

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Abstract

Glutathione peroxidase, one of the major antioxidants in the human brain, has been found to have decreased activity in patients suffering from multiple sclerosis (MS). This study compares the activity of lymphocyte glutathione peroxidase (L-GSH-px) in MS patients suffering from acute relapses with clinically stable MS patients and with control patients referred with nondemyelinating neurological diseases. All three groups showed an increase of mean enzymatic activity (MEA) during the observation period. The highest MEA in this study was observed in the MS groups. However, there were no significant differences in the L-GSH-px activity in the three groups. These results are not in accordance with previous investigations, and the need for further research in this field is emphasized.

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References

  1. R. C. Dickson and R. H. Tomlinson,Clin. Chim. Acta 16, 311 (1967).

    Article  PubMed  CAS  Google Scholar 

  2. J. C. Hansen, K. Overvad, U. Trap, and E. B. Thorling,Ugeskr. Læg. 147, 1911 (1985).

    PubMed  CAS  Google Scholar 

  3. G. E. Jensen and J. Clausen,Acta Pharmacol. Toxicol. 59 (suppl. 7), 450 (1986).

    Google Scholar 

  4. G. E. Jensen and J. Clausen,J. Neurol. Sci. 63, 45 (1984).

    Article  PubMed  CAS  Google Scholar 

  5. G. E. Jensen, G. Gissel-Nielsen, and J. Clausen,J. Neurol. Sci. 48, 61 (1980).

    Article  PubMed  CAS  Google Scholar 

  6. G. E. Jensen, V. K. S. Shukla, G. Gissel-Nielsen, and J. Clausen,Scand. J. Clin. Lab. Invest. 38, 309 (1978).

    Article  PubMed  CAS  Google Scholar 

  7. J. F. Kurtzke,Neurology 5, 580 (1955).

    PubMed  CAS  Google Scholar 

  8. J. Mai, P. S. Sørensen, and J. C. Hansen,BTER 24, 109 (1990).

    CAS  Google Scholar 

  9. W. I. McDonald and A. M. Halliday,Br. Med. Bull. 33, 4 (1977).

    PubMed  CAS  Google Scholar 

  10. H. S. Mickel,Perspect. Biol. Med. 18, 363 (1975).

    PubMed  CAS  Google Scholar 

  11. D. E. Paglia and W. N. Valentine,J. Lab. Clin. Med. 70, 158 (1967).

    PubMed  CAS  Google Scholar 

  12. G. A. Schumacher, G. Beebe, R. F. Kibler, et al.,Ann. NY Acad. Sci. 122, 552 (1965).

    Article  Google Scholar 

  13. J. Wikström, T. Westermarck, and J. Palo,Acta Neurol. Scand. 54, 287 (1976).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Central Hospital, Viborg, Denmark

    Per Schmidt Sørensen, Lene R. Nielsen & Troels Sørensen

  2. Institute of Environmental and Occupational Medicine, University of Aarhus, Aarhus, Denmark

    Jens C. Hansen

  3. Department of Neurology, Aarhus University Hospital, Aarhus, Denmark

    Jesper Mai

Authors
  1. Per Schmidt Sørensen
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  2. Jens C. Hansen
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  3. Jesper Mai
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  4. Lene R. Nielsen
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  5. Troels Sørensen
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Sørensen, P.S., Hansen, J.C., Mai, J. et al. Lymphocyte glutathione peroxidase activity during exacerbations in multiple sclerosis. Biol Trace Elem Res 33, 145–150 (1992). https://doi.org/10.1007/BF02784003

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  • DOI: https://doi.org/10.1007/BF02784003

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