Abstract
Since the last century, many physicians have been trying to utilize chemotherapy to replace conventional surgical treatment for cases of cancer of the oropharynx, larynx, and hypopharynx, which would otherwise be candidates for total laryngectomy. Some authors claim that the preservation rate of the larynx increases after treatment by chemotherapy, which even may take the place of routine surgical methods. However, when calculated in a more rigorous way following accepted statistical methods, what they claim is questionable. As a result, the routine application of chemotherapy in its present form is not advisable for curable squamous cell carcinoma of the head and neck region. Further research is required to justify its benefit.
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References
Wolf GT, Forestiere A, Ang K, et al. Workshop Report: Organ preservation strategies in advanced head and neck cancer. Head & Neck. 1999;21:689–693.
Demard F, Chauvei P, Santini J, et al. Response to chemotherapy as justification for modification of the therapeutic strategy for pharyngolaryngeal carcinomas. Head & Neck. 1990;12:225–231.
The Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991; 324:1685–1690.
Kraus DH, Pfister DG, Harrison LB, et al. Larynx preservation with combined chemotherapy and radiation therapy in advanced hypopharynx cancer. Otolarygol Head Neck Surg. 1994; 111:31–37.
Shirinian MH, Weber RS, Lippman SN, et al. Laryngeal preservation by induction chemotherapy plus radiotherapy in locally advanced head and neck cancers. The MD Anderson Cancer Center experience. Head & Neck. 1994; 16:39–44.
Clayman GL, Weber RS, Guillamondegui O, et al. Laryngeal preservation for advanced laryngeal and hypopharyngeal cancers. Arch Otolaryngol Head Neck Surg. 1995;121:219–223.
Lefebvre JL, Chevalier D, Luboinski B, et al. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer, Phase III trial. J Natl Cancer Inst. 1996; 88:890–899.
Samant S, Kumar P, Wan J, et al. Concomitant radiation therapy and targeted cisplatin chmotherapy for the treatment of advanced pyriform sinus carcinoma: disease control and preservation of organ function. Head & Neck. 1999;21:595–601.
Urba SG, Wolf GT, Bradford CR, et al. Neoadjuvant therapy for organ preservation in head and neck cancer. Laryngoscope. 2000;110:2074–2080.
Tucker HM. Conservation surgery for selected T3 glottic carcinoma. Proceedings of the 2nd World Congress on Laryngeal Cancer. Sydney, Elsevier Science, Amsterdam. 1994;494–496.
Spector JG, Sessions DG, Emami B, et al. Pyriform sinus carcinomas. Proceedings of the 2nd World Congress on Laryngeal Cancer. Sydney, Elsevier Science, Amsterdam. 1994;602–605.
Laccourreye O, Brasnu D, Bassot V, et al. Cisplatin-fluorouracil exclusive chemotherapy for T1 -T3N0 glottic squamous cell carcinoma complete clinical responders: Five-year results. J Clin Oncol. 1996;14:2331–2336.
Laccourreye O, Veivers D, Hans S, et al. Chemotherapy alone with curative intent in patients with invasive squamous cell carcinoma of the pharyngolarynx classified as Tl -T4N0M0 complete clinical responders. Cancer. 2001;92:1504–1511.
Laccourreye O, Veivers D, Bassot V, et al. Analysis of local recurrence in patients with selected Tl-3N0M0 squamous cell carcinoma of the true vocal cord managed with a platinum -based chemotherapy -alone regimen for cure. Ann Otol Rhinol Laryngol. 2002;lll:315–322.
Cummings BJ. Definitve radiation therapy for glottic cancer. Proceedings of the 2nd World Congress on Laryngeal Cancer. Sydney, Elsevier Science, Amsterdam. 1994;9–13.
Silver CE. Conservation surgery for supraglottic cancer. In: Silver CE, Ferlito A. Surgery for cancer of the larynx and related structures. 2nd Ed. WB Saunders Co, Philadelphia. 1996;123–156.
Laccourreye O, Weinstein G. Supracricoid partial laryngectomies for endolaryngeal carcinoma. In: Tu GY (Ed). Laryngeal and hypopharyngeal cancer: theory and clinical practice. Shandong Publishing House, Jinan, China. 2002;254–273.
Pignon JP, Bourhis J, Domenge C, et al. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: three meta -analyses using updated individual data. Lancet. 2000;355:949–955.
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Tu, G. Chemotherapy: Is it warranted in curable head and neck cancer?. Chin. J. Clin. Oncol. 1, 381–385 (2004). https://doi.org/10.1007/BF02761731
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DOI: https://doi.org/10.1007/BF02761731