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Non-protein amino acids in peptide design

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Abstract

An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the useα-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments andDPro-Xxx segments for nucleating ofβ-hairpin structures.β- andγ-amino acid residues have been used to expand the range of designed polypeptide structures.

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Authors and Affiliations

  1. Department of Physics, Indian Institute of Science, 560 012, Bangalore, India

    S. Aravinda & N. Shamala

  2. Molecular Biophysics Unit, Indian Institute of Science, 560 012, Bangalore, India

    Rituparna S. Roy & P Balaram

  3. Chemical Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur Campus, Jakkur PO, 560 064, Bangalore, India

    P Balaram

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  1. S. Aravinda
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  2. N. Shamala
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  4. P Balaram
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Dedicated to Professor C N R Rao on his 70th birthday

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Aravinda, S., Shamala, N., Roy, R.S. et al. Non-protein amino acids in peptide design. J Chem Sci 115, 373–400 (2003). https://doi.org/10.1007/BF02708230

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