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Tat, Tat-associated kinase, and transcription

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Journal of Biomedical Science

Abstract

The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb.

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  1. Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, NIH, 20892-0460, Bethesda, MD, USA

    Kuan-Teh Jeang

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Jeang, KT. Tat, Tat-associated kinase, and transcription. J Biomed Sci 5, 24–27 (1998). https://doi.org/10.1007/BF02253352

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  • DOI: https://doi.org/10.1007/BF02253352

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