Abstract
The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg;N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal sphincter pressure, whileN-butylscopolamine and nitroglycerin produced a significant decrease in contraction frequency. Therefore, dipyrone, in contrast to tramadol and indomethacin, exhibits spasmolytic activity in addition to analgesia in biliary pain.
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This study was sponsored by Hoechst AG, Frankfurt/M., Germany
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Brandstätter, G., Schinzel, S. & Wurzer, H. Influence of spasmolytic analgesics on motility of sphincter of oddi. Digest Dis Sci 41, 1814–1818 (1996). https://doi.org/10.1007/BF02088751
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DOI: https://doi.org/10.1007/BF02088751