Abstract
Although many infants with intraventricular haemorrhage (IVH) recover without hydrocephalus, little is known about how blood is cleared from the CSF pathways. Fibrinolytic activity was measured by the fibrin plate method in CSF from 11 normal infants and 17 infants with IVH. Normal CSF showed no fibrinolytic activity. All the samples taken less than 17 days from diagnosis of IVH samples taken between 17 and 60 days of IVH showed fibrinolytic activity. In 1 infant where 14 serial samples were taken, there was no detectable fibrinolysis up to 16 days after IVH but from 19 to 52 days there was definite fibrinolytic activity. Delayed endogenous fibrinolysis in the CSF is common after IVH but may, in some cases, be insufficient to prevent hydrocephalus.
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Abbreviations
- FDP:
-
fibrin degradation product
- IVH:
-
intraventricular haemorrhage
References
Astrup T, Mullertz S (1952) The fibrin plate method for estimating fibrinolytic activity. Arch Biochem Biophys 40: 346–351
De Vries LS, Larroche JC, Levene MI (1988). Intracranial Sequelae. In: Levene MI, Bennett MJ, Punt J (eds) Fetal and neonatal neurology and neurosurgery. Churchill Livingstone, Edinburgh, pp 346–352
Ellington E, Margolis G (1969) Block of arachnoid villus by subarachnoid haemorrhage. J Neurosurg 30: 651–657
Fodstad H, Nilsson IM (1981) Coagulation and fibronolysis in blood and cerebrospinal fluid after aneurysmal subarachnoid haemorrhage: effect of tranexamic acid (AMCA). Acta Neurochirurgica 56: 25–38
Gaffney PJ (1981) The fibrinolytic system. In Bloom AL, Thomas DP (eds) Haemostasis and thrombosis. Churchill Livingstone, Edinburgh, pp213–215
Hensey OJ, Morgan MEI, Cooke RWI (1984) Tranexamic acid in the prevention of pericentricular haemorrhage. Arch Dis Child 59: 719–721
Larroche J-C (1972) Post-haemorrhagic hydrocephalus in infancy. Biol Neonate 20: 287–299
Takashima S, Koga M, Tanaka K (1969) Fibrinolytic activity of human brain and cerebrospinal fluid. Br J Exp Pathol 50: 533–539
Tovi D, Nillson TM, Thulin C-A (1973) Fibrinolytic activity of the cerebrospinal fluid after subarachnoid haemorrhage. Acta Neurol Scand 49: 1–9
Tsementis SA, Honan WP, Nightingale S, Hitchocock ER, Meyer CHA (1990) Fibrinolytic activity after subarachnoid haemorrhage and the effect of tranexamic acid. Acta Neurochir 103: 116–121
Whitelaw A, Creighton L, Gaffney P (1991) Fibrinolytic activity in cerebrospinal fluid after intraventricular haemorrhage. Arch Dis Child 66: 808–809
Whitelaw A, Rivers RPA, Creighton L, Gaffney P (1992) Low dose intraventricular fibrinolytic treatment to prevent posthaemorrhagic hydrocephalus. Arch Dis Child 67: 12–14
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Whitelaw, A. Endogenous fibrinolysis in neonatal cerebrospinal fluid. Eur J Pediatr 152, 928–930 (1993). https://doi.org/10.1007/BF01957533
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DOI: https://doi.org/10.1007/BF01957533