Summary
The authors report the case of a 23-year-old obese nonalcoholic woman who developed severe liver damage resembling alcoholic hepatitis and cirrhosis after multiple attempts at weight reduction. It is suggested that repeated episodes of starvation and malnutrition can induce the development of alcoholic-like liver injury in some overweight patients. This report could serve as a warning against unbalanced and uncontrolled self-treatment of obesity.
Similar content being viewed by others
References
Adler M, Schaffner F: Fatty liver hepatitis and cirrhosis in obese patients. Am J Med 67:811–816, 1979
Miller DJ, Ishimaru H, Klatskin G: Non-alcoholic liver disease mimicking alcoholic hepatitis and cirrhosis. Gastroenterology 77:27, 1979 (abstract)
Ludwig J, Viggiano TR, McGill DB, Ott BJ: Non-alcoholic steatohepatitis. Mayo Clinic experiences with an unnamed disease. Mayo Clin Proc 55:434–438, 1980
Peters RL: Hepatic morphologic changes after jejunoileal bypass.In Progress in Liver Diseases, Vol VI. H Popper, F Schaffner (eds). New York, Grune and Stratton, 1979, pp 581–593
Marubbio AT, Rucker RD Jr, Schneider PD, Horstmann JP, Varco RL, Büchwald H: The liver in morbid obesity and following bypass surgery for obesity. Surg Clin North Am 59:1079–1093, 1979
Holzbach RT: Hepatic effects of jejunoileal bypass for morbid obesity. Am J Clin Nutr 30:43–51, 1977
Moxley RT, Pozefsky T, Lockwood DH: Protein nutrition and liver disease after jejuno-ileal bypass for morbid obesity. N Engl J Med 290:921–926, 1974
Haines NW, Baker AL, Boyer JL, Glagov S, Schneir M, Jaspan J, Ferguson DJ: Prognostic indicators, of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study. Hepatology 1:161–167, 1981
Sabesin S, Hawkins HL, Bertram PD, Mann JA, Peace RJ: Alcoholic hepatitis. Gastroenterology 74:276–286, 1978
Falchuk KR, Fiske SC, Haggitt RC, Federman M, Trey C: Pericentral hepatic fibrosis and intracellular hyalin in diabetes mellitus. Gastroenterology 78:535–541, 1980
Gerber MA, Orr W, Denk H, Schaffner F, Popper H: Hepatocellular hyaline in cholestasis and cirrhosis, its diagnostic significance. Gastroenterology 64:89–98, 1973
Partin JS, Partin JC, Schubert WK, McAdams AJ: Liver ultrastructure in abetalipoproteinemia: evolution of micronodular cirrhosis. Gastroenterology 67:107–118, 1974
Zimmerman HJ: Drug-induced liver disease. Drugs 16:25–45, 1978
Ludwig J: Drug effects on the liver. A tabular compilation of drugs and drug-related hepatic diseases. Dig Dis Sci 24:785–796, 1979
Maddrey WC, Boitnott JK: Drug-induced chronic liver disease. Gastroenterology 72:1348–1353, 1977
Pessayre D, Bichara M, Feldmann G, Degott C, Lotet F, Benhamou JP: Perhexiline maleate-induced cirrhosis. Gastroenterology 76:170–177, 1979
Itoh S, Tsukada Y: Clinico-pathological and electron microscopical studies on a coronary dilating agent: 4,4′-diethylaminoethoxyhexestrol-induced liver injury. Acta Hepatogastroenterol 20:204–215, 1973
Itoh S, Igarashi M, Tsukada Y, Ichinoe A: Nonalcoholic fatty liver with alcoholic hyalin after long-term glucocorticoid therapy. Acta Hepatogastroenterol 24:415–418, 1977
Danish Obesity Project: Randomised clinical trial of jejunoileal bypass versus medical treatment in morbid obesity. Lancet 2:1255–1257, 1979
Rozental P, Biava C, Spencer H, Zimmerman HJ: Liver morphology and function tests in obesity and during total starvation. Am J Dig Dis 12:198–208, 1967
Drenick EJ, Simmons F, Murphy JF: Effect on hepatic morphology of treatment of obeity by fasting, reducing diets and small-bowel bypass. N Engl J Med 282:829–834, 1970
Peura DA, Stromeyer FW, Johnson LF: Liver injury with alcoholic hyaline after intestinal resection. Gastroenterology 79:128–130, 1980
Craig RM, Neumann T, Jeejeebhoy KN, Yokoo H: Severe hepatocellular reaction resembling alcoholic hepatitis with cirrhosis after massive small bowel resection and prolonged total parenteral nutrition. Gastroenterology, 79:131–137, 1980
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Capron, JP., Delamarre, J., Dupas, JL. et al. Fasting in obesity. Digest Dis Sci 27, 265–268 (1982). https://doi.org/10.1007/BF01296926
Issue Date:
DOI: https://doi.org/10.1007/BF01296926