Summary
A significant proportion of patients with schizophrenia have increased homocysteine levels that are unrelated to psychopharmacological medication or nutrient deficiency in folate or cobalamin. This supports the hypothesis that inherent methylation deficiency is involved in the pathogenesis of schizophrenia.
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Regland, B., Johansson, B.V., Grenfeldt, B. et al. Homocysteinemia is a common feature of schizophrenia. J. Neural Transmission 100, 165–169 (1995). https://doi.org/10.1007/BF01271539
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DOI: https://doi.org/10.1007/BF01271539