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Quantitative aspects of reactive gliosis: A review

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Abstract

Recent studies of gliosis in a variety of animal models are reviewed. The models include brain injury, neurotoxic damage, genetic diseases and inflammatory demyelination. These studies show that reactive gliosis is not a stereotypic response, but varies widely in duration, degree of hyperplasia, and time course of expression of GFAP immunostaining, content and mRNA. We conclude that there are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

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  1. I. Hozumi

    Present address: Department of Neurology, Brain Research Institute, Niigata University, Asahimachi 1, 951, Niigata, Japan

Authors and Affiliations

  1. Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY

    W. T. Norton, D. A. Aquino, I. Hozumi & F. -C. Chiu

  2. Department of Neuroscience, Albert Einstein College of Medicine, 10461, Bronx, NY

    W. T. Norton, F. -C. Chiu & C. F. Brosnan

  3. Department of Pathology, Albert Einstein College of Medicine, 10461, Bronx, NY

    C. F. Brosnan

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Special issue dedicated to Dr. Alan N. Davison.

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Norton, W.T., Aquino, D.A., Hozumi, I. et al. Quantitative aspects of reactive gliosis: A review. Neurochem Res 17, 877–885 (1992). https://doi.org/10.1007/BF00993263

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