Abstract
High-resolution chromatographic profiles of urinary volatiles were quantitatively recorded and statistically evaluated for the female mice genetically differing in a small region of the major histocompatibility complex on the 17th chromosome. Both immature and estrogenized animals were evaluated. While there seem to be no specific volatile products of the histocompatibility genes, statistically significant differences were readily observed with the immature females of different haplotypes, involving the general range of secondary volatile metabolites. Their possible role in olfactory communication is discussed.
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Andrews, P. W., andBoyse, E.A. 1978. Mapping of an H-2-linked gene that influences mating preference in mice.Immunogenetics 6:265–268.
Bartke, A. 1974. Increased sensitivity of seminal vesicles to testosterone levels.J. Endocrinol. 60:145–148.
Bellamy, D., andCavies, V.J. 1981. Sexual attractants in rodent urine.J. Endocrinol. 51:xix.
Bronson, F.H. 1979. The reproductive ecology of the house mouse.Q. Rev. Biol. 54:265–299.
Chapman, V.M., andWhitten, W.K. 1969. The occurrence and inheritance of pregnancy block in inbred mice.Genetics 61 (Suppl.):s9 (abstract).
Fisher, R.A. 1948. Statistical Methods for Research Workers, 10th ed. Oliver and Boyd, Edinburgh.
Hoppe, P.C. 1975. Genetic and endocrine studies of the pregnancy-blocking pheromone of mice.J. Reprod. Fertil. 45:109–115.
Jones, R.B., andNowell, N.W. 1973. The coagulating glands as a source of aversive and aggression-inhibiting pheromone(s) in the male albino mouse.Physiol. Behav. 11:455–462.
Jorgenson, J.W. 1979. Investigation of the nature of chemical messengers in mammalian communication. PhD thesis. Indiana University, Bloomington.
Klein, J. 1975. Biology of the Histocompatibility-2 Complex. Springer-Verlag, New York.
Klein, J. 1978. H-2 Mutations: Their genetics and effect on immune function.Adv. Immunol. 26:55–146.
Klein, J., Figueroa, P., andKlein, D. 1982. H-2 haplotypes, genes, and antigens: Second listing.Immunogenetics 16:285–317.
Maruniak, J.A., Desjardins, C., andBronson, F.H. 1977. Dominant-subordinate relationships in castrated male mice bearing testosterone implants.Am. J. Physiol. 233:E495–499.
Mugford, R.A., andNowell, N.W. 1970. Pheromones and their effect on aggression in mice.Nature 226:967–968.
Nadeau, J.H., Wakeland, E.K., Götze, D., andKlein, J. 1981. The population genetics of the H-2 polymorphism in European and North African populations of the house mouse(Mus musculus L.).Genet. Res. Camb. 37:17–31.
Neter, J., Wasserman, W., andWhitmore, G.A. 1978. Applied Statistics, Chap. 19. Inferences in Simple Linear Regressions. Allyn and Bacon, Boston.
Novotny, M.V., Lee, M.L., andBartle, K.D. 1974. Some analytical aspects of the chromato graphic headspace concentration method using a porous polymer.Chromatographia 7:333–338.
Scott, J.W., andPfaff, D.W. 1970. Behavioral and electrophysiological responses of female mice to male urine odors.Physiol. Behav. 5;407–411.
Schwende, F.J., Wiesler, D., andNovotny, M. 1984. Volatile compounds associated with estrus in mouse urine: Potential pheromones.Experientia. 40:213–215.
Showhart, W.A. 1931. Economic Control of Quality of Manufactured Products. D. Van Nostrand, New York.
Simon, H.G. 1979. The genetics of intermale aggressive behavior in mice: Recent research and alternative strategies.Neurosci. Biobehav. Rev. 3:97–106.
Whitten, W.K., andChamplin, A.K. 1973. The role of olfaction in mammalian reproduction, pp. 109–123in R.O. Greep, (ed.). Handbook of Physiology, Endocrinology II, Part I, Chapter 5. American Physiological Society, Washington, D.C.
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Schwende, F.J., Jorgenson, J.W. & Novotny, M. Possible chemical basis for histocompatibility-related mating preference in mice. J Chem Ecol 10, 1603–1615 (1984). https://doi.org/10.1007/BF00988428
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DOI: https://doi.org/10.1007/BF00988428