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Caffeine and human behavior: Arousal, anxiety, and performance effects

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Abstract

A review of the recent literature shows the role of caffeine in the physiology, mood, and behavior of persons to be a complex one including changes in arousal, anxiety, and performance. Questions are raised as to what degree the physiological effects of caffeine are due to central nervous system stimulation and/or result from the release of catecholamines. Anxiety resulting from both high levels of caffeine (caffeinism) and caffeine withdrawal plus an association between caffeine and depression are discussed. Performance effects are mixed, with both increases and decreases reported. Effects on mental tasks are related to personality variables. The possible role of differences in initial sensitivity, adaptation to caffeine, and/or interactions with nicotine and alcohol is discussed. The present paper reviews these studies, discusses their implications for both clinical and experimental work, summarizes the major unresolved issues, and makes suggestions for new and continuing areas of research.

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References

  • Arnold, L. E. (1978). Methylphenidate vs. dextroamphetamine vs. caffeine in minimal brain dysfunction: Controlled comparison by placebo washout design with Bayes' analysis.Arch. Gen. Psychiat. 35: 463–473.

    PubMed  Google Scholar 

  • Ashton, H., Millman, J. E., Telford, R., and Thompson, J. W. (1974). The effect of caffeine, nitrazepam and cigarette smoking on the contingent negative variation in man.Electroencephalogr. Clin. Neurophysiol. 37: 59–71.

    PubMed  Google Scholar 

  • Ayers, J., Ruff, C. F., and Templer, D. I. (1976). Alcoholism, cigarette smoking, coffee drinking and extraversion.J. Stud. Alcohol 37: 983–985.

    PubMed  Google Scholar 

  • Baker, W. T., and Theologus, G. C. (1972). Effects of caffeine on visual monitoring.J. Appl. Psychol. 56: 422–427.

    PubMed  Google Scholar 

  • Bellet, S., Roman, L., DeCastro, O., Kim, K. E., and Keushbaum, A. (1969). Effects of coffee ingestion on catecholamine release.Metabolism 18: 288–291.

    PubMed  Google Scholar 

  • Bowen S., Taylor, K. M., and Gibb, I. A. McL. (1981). Effects of coffee and tea of blood levels and efficacy of antipsychotic drugs.Lancet 1: 1217–1218 (letter).

    Google Scholar 

  • Childs, J. M. (1978). Caffeine consumption and target scanning performance.Hum. Fact. 20: 91–96.

    Google Scholar 

  • Clubley, M., Henson, T., Peck, A. W., and Riddington, C. (1977). Effects of caffeine and cyclizine alone and in combination on human performance and subjective ratings (proceedings).Br. J. Clin. Pharmacol. 4: 652.

    Google Scholar 

  • Cohen, S., and Booth, G. H., Jr. (1975). Gastric acid secretion and lower-esophagealsphincter pressure in response to coffee and caffeine.N. Engl. J. Med. 293: 987.

    Google Scholar 

  • Colton, T., Gosselin, R. E., and Smith, R. P. (1968). The tolerance of coffee drinkers to caffeine.Clin. Pharmacol. Ther. 9: 31–39.

    PubMed  Google Scholar 

  • Connors, C. K. (1975). A placebo-crossover study of caffeine treatment of hyperkinetic children.Int. J. Ment. Health 4: 132–143.

    Google Scholar 

  • Costill, D. L., Dalsky, G. P., and Fink, W. J. (1978). Effects of caffeine ingestion on metabolism and exercise performance.Med. Sci. Sports 10: 155–158.

    PubMed  Google Scholar 

  • Dimaio, V. J. M., and Garriott, J. C. (1974). Lethal caffeine poisoning in a child.Forens. Sci. 3: 275.

    Google Scholar 

  • Dreisbach, R. H., and Pfeiffer, C. (1943). Caffeine withdrawal headache.J. Lab. Clin. Med. 28: 1212.

    Google Scholar 

  • Eysenck, H. J. (1962).Experiments with Drugs, Pergamon Press, New York.

    Google Scholar 

  • Eysenck, M. W., and Folkard, S. (1980). Personality, time of day, and caffeine: Some theroretical and conceptual problems in Revelle et al.J. Exp. Psychol. Gen. 109: 32–41.

    PubMed  Google Scholar 

  • Franks, H. M., Hagedom, H., Hensley, V. R., Hensley, W. J., and Starmer, G. A. (1975). The effects of caffeine on human performance, alone and in combination with ethanol.Psychopharmacologia 45: 177–181.

    PubMed  Google Scholar 

  • Furlong, F. W. (1975). Possible psychiatric significance of excessive coffee consumption.Can. Psychiat. Assoc. J. 20: 577–583.

    Google Scholar 

  • Garfinkel, B. D., Webster, C. D., and Sloman, L. (1975). Methylphenidate and caffeine in the treatment of children with minimal brain dysfunction.Am. J. Psychiat. 132: 723–728.

    PubMed  Google Scholar 

  • Gilliland, K. (1980). The interactive effect of introversion-extroversion with caffeine induced arousal on verbal performance.J. Res. Personal. 14: 482–492.

    Google Scholar 

  • Gilliland, K., and Andress, D. (1981). Ad lib caffeine consumption, symptoms of caffeinism and academic performance.Am. J. Psychiat. 138: 512–514.

    PubMed  Google Scholar 

  • Goldstein, A. (1964). Wakefulness caused by caffeine.Arch. Exp. Pathol. 248: 269.

    Google Scholar 

  • Goldstein, A., and Kaizer, S. (1969). Psychotropic effects of caffeine in man. III. A questionnaire survey of coffee drinkers and its effects in a group of housewives.Clin. Pharmacol. Ther. 10: 477–488.

    PubMed  Google Scholar 

  • Goldstein, A., Kaizer, S., and Whitby, O. (1969). Psychotropic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee.Clin. Pharmacol. Ther. 10: 489–497.

    PubMed  Google Scholar 

  • Goldstein, A., Warren, R., and Kaizer, S. (1965). Psychotropic effects of caffeine in man. I. Individual differences in sensitivity to caffeine-induced wakefulness.J. Pharmacol. Exp. Ther. 149: 156–159.

    PubMed  Google Scholar 

  • Graham, D. M. (1978). Caffeine—its identity, dietary sources, intake and biological effects.Nutr. Rev. 36: 97–102.

    PubMed  Google Scholar 

  • Greden, J. F. (1974). Anxiety or caffeinism: A diagnostic dilemma.Am. J. Psychiat. 131: 1089–1092.

    PubMed  Google Scholar 

  • Greden, J. F., Fontaine, P., Lubetsky, M., and Chamberlin, K. (1978). Anxiety and depression associated with caffeinism among psychiatric inmates.Am. J. Psychiat. 13: 963–966.

    Google Scholar 

  • Gross, M. D. (1975). Caffeine in the treatment of children with minimal brain dysfunction or hyperactive syndrome.Psychosomatics 16: 26–27.

    PubMed  Google Scholar 

  • Harrie, J. R. (1970). Caffeine and headache.JAMA 213: 628 (letter).

    Google Scholar 

  • Harvy, D. H., and Marsh, R. W. (1978). The effects of decaffeinated coffe versus whole coffee on hyperactive children.Dev. Med. Child Neurol. 20: 81–86.

    PubMed  Google Scholar 

  • Horning, M. G., Brown, L., Nowlin, J., Leitratanangkoon, K., Kellaway, P., and Zion, T. E. (1977). Use of saliva in therapeutic drug monitoring.Clin. Chem. 23: 157–164.

    PubMed  Google Scholar 

  • Hull, C. L. (1935). The influence of caffeine on mental and motor efficiency.J. Gen. Psychol. 13: 249–274.

    Google Scholar 

  • Humphreys, M. S., Revelle, W., Simon, L., and Gilliland, K. (1980). Individual differences in diurnal rhythms and multiple activation sites; A reply to M. W. Eysenck and Folkard,J. Exp. Psychol. Gen. 109: 42–48.

    PubMed  Google Scholar 

  • Innes, I. R., and Nickerson, M. (1975). Drugs acting on postganglionic adrenergic nerve endings and structures innervated by them (sympathomimetic drugs). In Goodman, L. S., and Gilman, A. (eds.),The Pharmacological Basis of Therapeutics, Macmillan, New York.

    Google Scholar 

  • Janssen, R. H., Mattie, P. C., Plooij-Van, G., and Werre, P. F. (1978). The effects of a depressant and a stimulant drug on the contingent negative variation.Biol. Psychol. 6: 209–218.

    PubMed  Google Scholar 

  • Jung, R. T., Shetty, P. S., James, W. P. T., Barrand, M. A., and Callingham, B. A. (1981). Caffeine—its effects on catecholamines and metabolism in lean and obese humans.Clin. Sci. 60: 527–535.

    PubMed  Google Scholar 

  • Keister, M., and McLaughlin, R. (1972). Vigilance performance related to extroversion-introversion and caffeine.J. Exp. Res. Personal. 6: 5–11.

    Google Scholar 

  • Kinsbourne, M. (1973).Personality of hyperactive children and stimulant therapy. Presented at the 81st meeting of the American Psychological Association, Montreal, Canada.

  • Klein, R. H., and Salzman, L. F. (1975). Paradoxical effects of caffeine.Percept. Motor Skills 40: 126.

    PubMed  Google Scholar 

  • Kozlowski, L. T. (1976). Effects of caffeine consumption on nicotine consumption.Psychopharmacology 47: 165–168.

    Google Scholar 

  • Leshner, A. I. (1978).An Introduction to Behavioral Endocrinology, Oxford University Press, New York, p. 308.

    Google Scholar 

  • Levi, L. (1967). Effect of coffee on the function of the sympatho-adrenomedullary system in man.Acta Med. Scand. 181: 431–438.

    PubMed  Google Scholar 

  • May, D. C., Long, T., Madden, R., Hurst, H. E., and Jarboe, C. H. (1981). Caffeine toxicity secondary to street drug ingestion.Ann. Emerg. Med. 10: 549 (letter).

    Google Scholar 

  • Miller, J. L., Jr. (1960). Caffeine, chocolate, and withdrawal headaches.Nwest Med. 59: 502.

    Google Scholar 

  • Naismith, D. J., Akinyanju, P. A., Szanto, S., and Yudkin, J. (1970). The effect in volunteers of coffee and decaffeinated coffee on blood glucose, insulin, plasma lipids and some factors involved in blood clotting.Nutr. Metab. 12: 144.

    PubMed  Google Scholar 

  • Neil, J. F., Himmelhoch, J. M., Mallinger, A. G., Mallinger, J., and Hanin, I. (1978). Caffeinism complicating hypersomic depressive episodes.Compr. Psychiat. 19: 377–385.

    PubMed  Google Scholar 

  • Pansky, B. (1975).Dynamic Anatomy and Physiology, Macmillan, New York, pp. 489–502.

    Google Scholar 

  • Paroli, E. (1972). Psychopharmacological aspects of coffee and of caffeine.Minerva Med. Guil. (Torino) 63: 3319–3323 (abstr.).

    Google Scholar 

  • Parsons, W. D., and Neims, A. H. (1978). Effect of smoking on caffeine clearance.Clin. Pharmacol. Ther. 24: 40–45.

    PubMed  Google Scholar 

  • Perkins, R., and Williams, M. H. (1975). Effects of caffeine upon maximal muscular endurance of females.Med. Sci. Sports 7: 221–224.

    PubMed  Google Scholar 

  • Pollock, V. E., Teasdale, T., Stern, J., and Volavka, J. (1981). Effects of caffeine on resting EEG and response to sine wave modulated light.Electroencephalogr. Clin. Neurophysiol. 51: 470–476.

    PubMed  Google Scholar 

  • Putz-Anderson, V., Setzer, J. V., and Croxton, J. S. (1981). Effects of alcohol, caffeine and methyl chloride on man.Psychiat. Rep. 48: 715–725.

    Google Scholar 

  • Reicchard, C. C., and Elder, S. T. (1977). The effects of caffeine on reaction time in hyperkinetic and normal children.Am. J. Psychiat. 134: 144–148.

    PubMed  Google Scholar 

  • Revelle, W., Amaral, P., and Turiff, S. (1976). Introversion/extroversion, time, stress, and caffeine: Effect on verbal performance.Science 192: 149–150.

    PubMed  Google Scholar 

  • Revelle, W., Humphreys, M. S., Simon, L., and Gilliland, K. (1980). The interactive effect of personality, time of day, and caffeine: A test of the arousal model.J. Exp. Psychol. Gen. 109: 1–31.

    PubMed  Google Scholar 

  • Ritchie, J. M. (1975). Central nervous system stimulants (continued), the xanthines. In Goodman, L. S., and Gilman, A. (eds.),The Pharmacological Basis of Therapeutics, Macmillan, New York.

    Google Scholar 

  • Robertson, D., Frolich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., and Oates, J. A. (1978). Effects of caffeine on plasma renin activity, catecholamines and blood pressure.N. Eng. J. Med. 298: 181–186.

    Google Scholar 

  • Roller, L. (1981). Caffeinism—subjective quantitative aspects of withdrawal syndrome.Med. J. Aust. 1: 146 (letter).

    Google Scholar 

  • Schachter, S., and Singer, J. E. (1962). Cognitive, social, and physiological determinants of emotional state.Psychol. Rev. 69: 379–399.

    PubMed  Google Scholar 

  • Schnackenberg, R. (1973). Caffeine as a substitute for Schedule II stimulants in hyperkinetic children.Am. J. Psychiat. 130: 796–798.

    PubMed  Google Scholar 

  • Schnackenberg, R. C. (1975). Caffeine therapy for hyperkinetic children.Curr. Psychiat. Ther. 15: 39–44.

    PubMed  Google Scholar 

  • Selbach, H. (1973). Caffeine, Kaffee, kupfschmerz and migrane.Med. Klin. 68: 642.

    PubMed  Google Scholar 

  • Smith, D. L., Tong, J. E., and Leigh, G. (1977). Combined effects of tobacco and caffeine on the components of choice reaction time, heart rate, and hand steadiness.Percept. Motor Skills 45: 635–639.

    PubMed  Google Scholar 

  • Solomon, R. L., and Corbit, J. D. (1974). An opponent-process theory of acquired motivation: Temporal dynamic of affect.Psychol. Rev. 81: 119–145.

    PubMed  Google Scholar 

  • Stephenson, P. E. (1977). Physiologic and psychotropic effects of caffeine on man, a review.J. Am. Diet. Assoc. 71: 240–247.

    PubMed  Google Scholar 

  • Sullivan, J. L. (1977). Caffeine poisoning in an infant.J. Pediatr. 90: 1022–1023.

    PubMed  Google Scholar 

  • Tecce, J. J., and Cole, J. O. (1974). Amphetamine effects in man: Paradoxical drowsiness and lowered electrical brain activity.Science 185: 451.

    PubMed  Google Scholar 

  • Tepperman, J. (1965).Metabolic and Endrocrine Physiology, An Introductory Text, Year Book Medical, Chicago, p. 129.

    Google Scholar 

  • Thompson, R. F. (1975).Introduction to Physiological Psychology, Harper and Row, New York, pp. 167–168.

    Google Scholar 

  • Truitt, E. B., Jr. (1971). The xanthines. In DiPalma, J. R. (ed.),Drill's Pharmacology in Medicine, McGraw-Hill, New York.

    Google Scholar 

  • Turner, T. E., and Cravey, R. H. (1977). A fatal ingestion of caffeine.Clin. Toxicol. 10: 341–344.

    PubMed  Google Scholar 

  • White, B. C., Lincoln, C. A., Pearce, N. W., Reeb, R., and Varda, C. (1980). Anxiety and muscle tension as consequences of caffeine withdrawal.Science 209: 1547–1548.

    PubMed  Google Scholar 

  • Winstead, D. K. (1976). Coffee consumption among psychiatric inpatients.Am. J. Psychiat. 133: 1447–1450.

    PubMed  Google Scholar 

  • Wolpaw, J. R., and Penny, J. K. (1978). Effects of ethanol, caffeine, and placebo on the auditory evoked response.Electroencephalogr. Clin. Neurophysiol. 44: 568–574.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Framingham State College, 01701, Framingham, Massachusetts

    Deborah A. Sawyer

  2. Department of Psychology, Framingham State College, 01701, Framingham, Massachusetts

    Harry L. Julia

  3. 02173, Lexington, Massachusetts

    Alan C. Turin Ph.D.

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  1. Deborah A. Sawyer
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  2. Harry L. Julia
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  3. Alan C. Turin Ph.D.
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Sawyer, D.A., Julia, H.L. & Turin, A.C. Caffeine and human behavior: Arousal, anxiety, and performance effects. J Behav Med 5, 415–439 (1982). https://doi.org/10.1007/BF00845371

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