Skip to main content
SpringerLink
Log in

Molecular properties of the fungal plasma-membrane [H+]-ATPase

  • Mini-Review
  • Published:
Journal of Bioenergetics and Biomembranes Aims and scope Submit manuscript

Abstract

The fungal plasma membrane contains a proton-translocating ATPase that is closely related, both structurally and functionally, to the [Na+, K+]-, [H+, K+]-, and [Ca2+]-ATPases of animal cells, the plasma-membrane [H+]-ATPase of higher plants, and several bacterial cation-transporting ATPases. This review summarizes currently available information on the molecular genetics, protein structure, and reaction cycle of the fungal enzyme. Recent efforts to dissect structure-function relationships are also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aaronson, L. R., Hager, K. M., Davenport, J. W., Mandala, S. M., Chang, A., Speicher, D. W., and Slayman, C. W. (1988)J. Biol. Chem. 263, 14552–14558.

    Google Scholar 

  • Addison, R. (1986)J. Biol. Chem. 261, 14896–14901.

    Google Scholar 

  • Addison, R., and Scarborough, G. A. (1982)J. Biol. Chem. 257, 10421–10426.

    Google Scholar 

  • Addison, R., and Scarborough, G. A. (1986)Biochemistry 25, 4071–4076.

    Google Scholar 

  • Amory, A., and Goffeau, A. (1982)J. Biol. Chem. 257, 4723–4730.

    Google Scholar 

  • Amory, A., Foury, F., and Goffeau, A. (1980)J. Biol. Chem. 255, 9353–9357.

    Google Scholar 

  • Amory, A., Goffeau, A., McIntosh, D. B., and Boyer, P. B. (1982)J. Biol. Chem. 257, 12509–12516.

    Google Scholar 

  • Bowman, B. J. (1983)J. Biol. Chem. 258, 13002–13007.

    Google Scholar 

  • Bowman, B. J., and Slayman, C. W. (1979)J. Biol. Chem. 254, 2928–2934.

    Google Scholar 

  • Bowman, B. J., Blasco, F., and Slayman, C. W. (1981)J. Biol. Chem. 256, 12343–12349.

    Google Scholar 

  • Brooker, R. J., and Slayman, C. W. (1982)J. Biol. Chem. 257, 12051–12055.

    Google Scholar 

  • Brooker, R. J., and Slayman, C. W. (1983a)J. Biol. Chem. 258, 222–226.

    Google Scholar 

  • Brooker, R. J., and Slayman, C. W. (1983b)J. Biol. Chem. 258, 8827–8832.

    Google Scholar 

  • Cantley, L. C., Jr., Cantley, L. G., and Josephson, L. (1978)J. Biol. Chem. 253, 7361–7368.

    Google Scholar 

  • Chadwick, C. C., Goormaghtigh, E., and Scarborough, G. A. (1987)Arch. Biochem. Biophys. 252, 348–356.

    Google Scholar 

  • Cid, A., and Serrano, R. (1988)J. Biol. Chem. 263, 14134–14139.

    Google Scholar 

  • Cid, A., Perona, R., and Serrano, R. (1987)Curr. Genet. 12, 105–110.

    Google Scholar 

  • Dame, J. B., and Scarborough, G. A. (1980)Biochemistry 19, 2931–2937.

    Google Scholar 

  • Dame, J. B., and Scarborough, G. A. (1981)J. Biol. Chem. 256, 10724–10730.

    Google Scholar 

  • Davenport, J. W., and Slayman, C. W. (1988)J. Biol. Chem. 263, 16007–16013.

    Google Scholar 

  • Di Pietro, A., and Goffeau, A. (1985)Eur. J. Biochem. 148, 35–39.

    Google Scholar 

  • Dufour, J.-P., and Goffeau, A. (1978)J. Biol. Chem. 253, 7026–7032.

    Google Scholar 

  • Dufour, J.-P., Goffeau, A., and Tsong, T. Y. (1982)J. Biol. Chem. 257, 9365–9371.

    Google Scholar 

  • Dufour, J.-P., and Goffeau, A. (1980).J. Biol. Chem. 255, 10591–10598.

    Google Scholar 

  • Dufour, J.-P., Amory, A., and Goffeau, A. (1988) InMethods in Enzymology (Fleischer, S., and Fleischer, B., eds.), Vol. 157, Academic Press, San Diego, pp. 513–528.

    Google Scholar 

  • Engelman, D. M., Steitz, T. A., and Goldman, A. (1986)Annu. Rev. Biophys. Biophys. Chem. 15, 321–353.

    Google Scholar 

  • Foury, F., Amory, A., and Goffeau, A. (1981)Eur. J. Biochem. 119, 395–400.

    Google Scholar 

  • Ghislain, M., Schlesser, A., and Goffeau, A. (1987)J. Biol. Chem. 262, 17549–17555.

    Google Scholar 

  • Goormaghtigh, E., Chadwick, C., and Scarborough, G. A. (1986)J. Biol. Chem. 261, 7466–7471.

    Google Scholar 

  • Hager, K. M., Mandala, S. M., Davenport, J. W., Speicher, D. W., Benz, E. J., and Slayman, C. W. (1986)Proc. Natl. Acad. Sci. USA 83, 7693–7697.

    Google Scholar 

  • Harper, J. F., Surowy, T. K., and Sussman, M. R. (1989)Proc. Natl. Acad. Sci. USA 86, 1234–1238.

    Google Scholar 

  • Kasher, J. S., Allen, K. E., Kasamo, K., and Slayman, C. W. (1986)J. Biol. Chem. 261, 10808–10813.

    Google Scholar 

  • Koland, J. G., and Hammes, G. G. (1986)J. Biol. Chem. 261, 5936–5942.

    Google Scholar 

  • Malpartida, F., and Serrano, R. (1981)Eur. J. Biochem. 116, 413–417.

    Google Scholar 

  • Mandala, S. M., and Slayman, C. W. (1988)J. Biol. Chem. 263, 15122–15128.

    Google Scholar 

  • Mandala, S. M., and Slayman, C. W. (1989)J. Biol. Chem. 264, in press.

  • McCusker, J. H., Perlin, D. S., and Haber, J. E. (1987)Mol. Cell. Biol. 7, 4082–4088.

    Google Scholar 

  • Meade, J. C., Shaw, J., Lemaster, S., Gallagher, G., and Stringer, J. R. (1987)Mol. Cell. Biol. 7, 3937–3946.

    Google Scholar 

  • Money, N. P., Aaronson, L. R., Slayman, C. W., and Slayman, C. L. (1988)Biophys. J. 53, 137a.

    Google Scholar 

  • Nakamoto, R. K., Rao, R., and Slayman, C. W. (1989)Ann. N.Y. Acad. Sci., in press.

  • Needleman, S. B., and Wunsch, C. D. (1970)J. Mol. Biol. 48, 443–453.

    Google Scholar 

  • Pardo, J. P., and Slayman, C. W. (1988)J. Biol. Chem. 263, 18664–18668.

    Google Scholar 

  • Pardo, J. P., and Slayman, C. W. (1989)J. Biol. Chem. 264, 9373–9379.

    Google Scholar 

  • Perline, D. S., Kasamo, K., Brooker, R. J., and Slayman, C. W. (1984)J. Biol. Chem. 259, 7884–7892.

    Google Scholar 

  • Perlin, D. S., San Francisco, M. J. D., Slayman, C. W., and Rosen, B. P. (1986)Arch. Biochem. Biophys. 248, 53–61.

    Google Scholar 

  • Perlin, D. S., Brown, C. L., and Haber, J. E. (1988)J. Biol. Chem. 263, 18118–18122.

    Google Scholar 

  • Perona, R., and Serrano, R. (1988)Nature (London) 334, 438–440.

    Google Scholar 

  • Portillo, F., and Serrano, R. (1988)EMBO J. 7, 1793–1798.

    Google Scholar 

  • Rao, R., Nakamoto, R. K., and Slayman, C. W. (1989) InProceedings of the Smith, Kline, and French Research Symposium on Ion Transport (Poste, G. H., and Rink, T. J., eds.), Academic Press, New York, in press.

    Google Scholar 

  • Rao, U. S., Hennessey, J. P., Jr., and Scarborough, G. A. (1988)Anal. Biochem. 173, 251–264.

    Google Scholar 

  • Ronjat, M., Lacapere, J. J., Dufour, J.-P., and Dupont, Y. (1987)J. Biol. Chem. 262, 3146–3153.

    Google Scholar 

  • Sanders, D., Hansen, U.-P., and Slayman, C. L. (1981)Proc. Natl. Acad. Sci. USA 78, 5903–5907.

    Google Scholar 

  • Schlesser, A., Ulaszewki, S., Ghislain, M., and Goffeau, A. (1988)J. Biol. Chem. 263, 19480–19487.

    Google Scholar 

  • Serrano, R. (1988)Biochim. Biophys. Acta 947, 1–28.

    Google Scholar 

  • Serrano, R., Kielland-Brandt, M. C., and Fink, G. R. (1986a)Nature (London) 319, 689–693.

    Google Scholar 

  • Serrano, R., Montesinos, C., and Cid, A. (1986b)FEBS Letts. 208, 143–146.

    Google Scholar 

  • Slayman, C. L., and Sanders, D. (1984). InHydrogen Ion Transport in Epithelia (Forte, J. G., Warnock, D. G., and Rector, F. C., eds.), Wiley, New York, pp. 47–56.

    Google Scholar 

  • Slayman, C. L., and Sanders, D. (1985)Biochem. Soc. Symp. 50, 11–29.

    Google Scholar 

  • Slayman, C. L., and Zuckier, G. R. (1989)Ann. N.Y. Acad. Sci., in press.

  • Smith, K. E., and Hammes, G. G. (1988)J. Biol. Chem. 263, 13774–13778.

    Google Scholar 

  • Smith, R., and Scarborough, G. A. (1984)Anal. Biochem. 138, 156–163.

    Google Scholar 

  • Smith, R. L., Zinn, K., and Cantley, L. C. (1980)J. Biol. Chem. 255, 9852–9859.

    Google Scholar 

  • Sussman, M. R., and Slayman, C. W. (1983)J. Biol. Chem. 258, 1839–1843.

    Google Scholar 

  • Sussman, M. R., Strickler, J. E., Hager, K. M., and Slayman, C. W. (1987)J. Biol. Chem. 262, 4569–4573.

    Google Scholar 

  • Taylor, W. R., and Green, N. M. (1989)Eur. J. Biochem. 179, 241–248.

    Google Scholar 

  • Ulaszewski, S., Grenson, M., and Goffeau, A. (1983)Eur. J. Biochem. 130, 235–239.

    Google Scholar 

  • Ulaszewski, S., Coddington, A., and Goffeau, A. (1986)Curr. Genet. 10, 359–364.

    Google Scholar 

  • Ulaszewski, S., Balzi, E., and Goffeau, A. (1987a)Mol. Gen. Genet. 207, 38–46.

    Google Scholar 

  • Ulaszewski, S., Van Herck, J.-C., Dufour, J.-P., Kulpa, J., Nieuwenhuis, B., and Goffeau, A. (1987b)J. Biol. Chem. 262, 223–228.

    Google Scholar 

  • Villalobo, A., Boutry, M., and Goffeau, A. (1981)J. Biol. Chem. 256, 12081–12087.

    Google Scholar 

  • Walker, J. E., Saraste, M., Runswick, M. J., and Gay, N. J. (1982)EMBO J. 1, 945–951.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human Genetics, Yale School of Medicine, 06510, New Haven, Connecticut

    Robert K. Nakamoto & Carolyn W. Slayman

  2. Department of Cellular and Molecular Physiology, Yale School of Medicine, 06510, New Haven, Connecticut

    Carolyn W. Slayman

Authors
  1. Robert K. Nakamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carolyn W. Slayman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakamoto, R.K., Slayman, C.W. Molecular properties of the fungal plasma-membrane [H+]-ATPase. J Bioenerg Biomembr 21, 621–632 (1989). https://doi.org/10.1007/BF00808117

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00808117

Key Words

Search

Navigation