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Detection of substance use disorders in severely mentally ill patients

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Abstract

Severe mental illness is frequently complicated by substance use disorder. Approximately half of the severely mentally ill patients treated in acute care psychiatric settings have abused one or more of these substances. Despite the high rate of comorbidity, substance use disorders are generally not detected in acute care psychiatric settings, leading to incorrect diagnoses and ineffective treatments. The reasons for nondetection are complex, and research is needed to refine instruments and procedures for the detection of substance abuse in the severely mentally ill population. Nevertheless, clinicians can make better use of existing techniques of multimodal assessment to increase significantly the rate of accurate detection.

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References

  • Alterman, A.I., & Erdlen, D.L. (1983). Illicit substance use in hospitalized psychiatric patients: Clinical observations. Journal of Psychiatric Research and Evaluation, 5, 377–380.

    Google Scholar 

  • Alterman, A.I., Erdlen, F.R., McLellan, A.T., & Mann, S.C. (1980). Problem drinking in hospitalized schizophrenic patients. Addictive Behaviors, 5, 273–276.

    Google Scholar 

  • Alterman, A.I., Erdlen, D.L., LaPorte, D.J., & Erdlen, F.R. (1982). Effects of illicit drug use in an inpatient psychiatric population. Addictive Behaviors, 7, 231–242.

    Google Scholar 

  • Ananth, J., Vandewater, S., Kamal, M., Broksky, A., Gamal, R., Miller, M. (1989). Missed diagnosis of substance abuse in psychiatric patients. Hospital and Community Psychiatry, 4, 297–299.

    Google Scholar 

  • Babor, T.F., De La Fuente, J.R., Saunders, J., & Grant, M. (1989a). AUDIT: The alcohol use disorders identification test, guidelines for use in primary health care. Geneva: World Health Organization.

    Google Scholar 

  • Babor, T.F., Kranzler, H.R., & Lauerman, R.J. (1989b). Early detection of harmful alcohol consumption: Comparison of clinical, laboratory, and self-report screening procedures. Addictive Behaviors, 14, 139–157.

    Google Scholar 

  • Babor, T.F., Stephen, R.S., & Marlatt, G.A. (1987). Verbal report methods in clinical research on alcoholism: Response bias and its minimization. Journal of Studies on alcohol, 48, 410–424.

    Google Scholar 

  • Barbee, J.G., Clark, P.D., Crapanzano, M.S., Heintz, G.C. & Kehoe, C.E. (1989). Alcohol and substance abuse among schizophrenic patients presenting to an emergency psychiatric service. Journal Nervous and Mental Disease 177, 400–407.

    Google Scholar 

  • Bartels, S.J., Drake, R.E., Wallach, M.A., & Freeman, D.F. (1991). Characteristic hostility in schizophrenic outpatients. Schizophrenia Bulletin, 17, 163–171.

    Google Scholar 

  • Bartels, S.J., Teague, G.B., Drake, R.E., Clark, R.E., Bush, P., & Noordsy, D.L. (in press). Service utilization and costs associated with substance use disorder among severely mentally ill patients. Journal of Nervous and Mental Disease.

  • Bernadt, M.W., Taylor, C., Mumford, J., Smith, B. & Murray, R.M. (1982). Comparison of questionnaire and laboratory tests in the detection of excessive drinking and alcoholism. Lancet, 1(8267), 325–328.

    Google Scholar 

  • Blumberg, A.G., Cohen, M., Heaton, A.M., & Klein, D.F. (1971). Covert drug abuse among voluntary hospitalized psychiatric patients. Journal American Medical Association, 217, 1659–1661.

    Google Scholar 

  • Bowers, M.B., Mazure, C.M., Nelson, C.J., & Jatlow, P.I. (1990). Psychotogenic drug use and neuroleptic response. Schizophrenia Bulletin, 16, 81–85.

    Google Scholar 

  • Boyd, J.H., Burke, J.D., Gruenberg, C.E., Holzer, C.E., Rae, D.S., George, L.K., Karno, M., Stoltzman, R., McEvoy, L. & Nestadt, G. (1984). Exclusion criteria of DSM-III. Archives of General Psychiatry, 41, 983–989.

    Google Scholar 

  • Brady, K., Anton, R., Ballenger, J.C., Lydiard, B., Adinoff, B., & Selander, J. (1990). Cocaine abuse among schizophrenic patients. American Journal of Psychiatry, 147, 1164–1167.

    Google Scholar 

  • Brady, K., Casto, S., Lydiard, B., Malcolm, R., & Arana, G. (1991, May). Substance abuse in psychiatric inpatients. Presented at the annual convention of the American Psychiatric Association, New Orleans.

  • Ciarlo, D.A., Shader, R.I. (Eds). (1991). Clinical Manual of Chemical Dependence. Washington, D.C.: American Psychiatric Press.

    Google Scholar 

  • Clark, R.E. & Drake, R.E. (submitted). Expenditures of time and money by families of persons with severe mental illness and substance use disorder

  • Convit, A., Nemes, Z.C., & Volavka, J. (1988). History of phencyclidine use and repeated assaults in newly admitted young schizophrenic men. American Journal of Psychiatry, 145, 1176.

    Google Scholar 

  • Cox, R.A., & Crifasi, J.A. (1990). A comparison of a commercial microdiffusion method and gas chromatography for ethanol analysis. Journal of Analytic Toxicology, 14, 211–212.

    Google Scholar 

  • Crowley, T.J., Chesluk, D., Dilts, S., & Hart, R. (1974). Drug and alcohol abuse among psychiatric admissions. Archives of General Psychiatry, 30, 13–20.

    Google Scholar 

  • Cuffel, B.J. (in press). Prevalence estimates of substance abuse in schizophrenia and their correlates. Journal of Nervous and Mental Disease.

  • Damron, S.W. & Simpson, W.R. (1985, August). Substance abuse and schizophrenia: A health maintenance perspective. Presented at the 93rd annual meeting of the American Psychological Association, Los Angeles, CA.

  • Dixon, L., Haas, G., Weiden, P., Sweeney, J., & Frances, A. (1990). Acute effects of drug abuse in schizophrenic patients: Clinical observations and patients' self-reports. Schizophrenia Bulletin, 16, 69–79.

    Google Scholar 

  • Drake, R.E., Antosca, L., Noordsy, D.L., Bartels, S.J., & Osher, F.C. (1991a). Specialized services for the dually diagnosed. In Dual Diagnosis of Major Mentall Illness and Substance Disorder, edited by Minkoff, K., & Drake, R.E. San Francisco: Jossey-Bass.

    Google Scholar 

  • Drake, R.E., McHugo, G.J., & Noordsy, D.L. (in press). Treatment of alcoholism among schizophrenic outpatients: 4-year outcomes. American Journal of Psychiatry.

  • Drake, R.E., Osher, F.C., Noordsy, D.L., Hurlbut, S.C., Teague, G.B., & Beaudett, M.S. (1990). Diagnosis of alcohol use disorders in schizophrenia. Schizophrenia Bulletin, 16, 57–67.

    Google Scholar 

  • Drake, R.E., Osher, F.C., & Wallach, M.A. (1989). Alcohol use and abuse in schizophrenia: A prospective community study. Journal Nervous and Mental Disease 177, 408–414.

    Google Scholar 

  • Drake, R.E., Teague, G.B., Clark, R.E., Bartels, S.B., & Noordsy, D.L. (1992). New Hampshire study of case management for dually diagnosed clients. NIMH grants R18-MH-46072, R01-MH-47567, K02-MH-00839, NIAAA R01-AA-08341.

  • Drake, R.E. & Wallach, M.A. (1989). Substance abuse among the chronic mentally ill. Hospital and Community Psychiatry, 40, 1041–1046.

    Google Scholar 

  • Drake, R.E., Wallach, M.A., Teague, G.B., Freeman, D.H., Paskus, T.S., & Clark, T.A. (1991b). Housing instability and homelessness among rural schizophrenics. American Journal of Psychiatry, 148, 330–336.

    Google Scholar 

  • Fischer, P.J., Breakey, W.R., Nestadt, G., Romanoski, A.J., Ross, A., & Royall, R.M. (1991, May). Correlates of dual diagnosis in a Baltimore homeless population. Presented at the annual convention of the American Psychiatric Association, New Orleans.

  • Fuller, R.K., Lee, K.K., & Gordis, E. (1988). Validity of self report in alcoholism research: Results of a Veterans Administration cooperative study. Alcoholism: Clinical and Experimental Research, 12, 201–205.

    Google Scholar 

  • Galanter, M., Castaneda, R., & Fermen, J. (1988). Substance abuse among general psychiatric patients: Place of presentation, diagnosis, and treatment. American Journal of Drug and Alcohol Abuse, 14, 211–235.

    Google Scholar 

  • Gold, M.S., & Dackis, C.A. (1986). Role of the laboratory in evaluation of suspected drug abusers. Journal of Clinical Psychiatry, 47(Suppl. 1), 17–23.

    Google Scholar 

  • Hall, R.C.W., Popkin, M.K., Devaul, R., & Stickney, S.K. (1977). The effect of unrecognized drug abuse on diagnosis and therapeutic outcome. American Journal of Drug and Alcohol Abuse, 4, 455–465.

    Google Scholar 

  • Hansen, H.J., Caudill, S., & Boone, J. (1985). Crisis in drug testing: Results of CDC blind study. Journal of the American Medical Association, 253, 2382–2387.

    Google Scholar 

  • Hedlund, J.L., & Vieweg, B.W. (1984). The Michigan Alcoholism Screening Test (MAST): A comprehensive review. Journal of Operational Psychiatry, 15, 55–65.

    Google Scholar 

  • Hellerstein, D.J., & Meehan, B. (1987). Outpatient group therapy for schizophrenic substance abusers. American Journal of Psychiatry, 144, 1337–1339.

    Google Scholar 

  • Hughes, J.R., Hatsukami, D.K., Mitchell, J.E., & Dahlgren, L.A. (1986). Prevalence of smoking among psychiatric patients. American Journal of Psychiatry, 143, 993–997.

    Google Scholar 

  • Koegel, P., & Burnam, M.A. (1987). The epidemiology of alcohol abuse and dependence among the homeless: Findings from the inner city of Los Angeles. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism.

    Google Scholar 

  • Kofoed, L.L. (1991). Assessment of comorbid substance abuse and other major psychiatric illnesses. In Dual Diagnosis of Major Mental Illness and Substance Disorder, edited by Minkoff, K., & Drake, R.E. San Francisco: Jossey-Bass.

    Google Scholar 

  • Kofoed, L., Kania, J., Walsh, T., & Atkinson, R.M. (1986). Outpatient treatment of patients with substance abuse and coexisting psychiatric disorders. American Journal of Psychiatry, 143, 867–872.

    Google Scholar 

  • Knudson, P. & Vilmar, T. (1984). Cannabis and neuroleptic agents in schizophrenia. Acta Psychiatrica Scandinavia, 69, 162–174.

    Google Scholar 

  • Lehman, A.F. (1992). Personal communication regarding NIDA grant R01-DA05114.

  • Lehman, A.F., Myers, P., & Corty, E. (1989). Assessment and classification of patients with psychiatric and substance abuse syndromes. Hospital and Community Psychiatry, 40, 1019–1025.

    Google Scholar 

  • Lieberman, J.A., Kinon, B.J., & Loebel, A.D. (1990). Dopaminergic mechanisms in idiopathic and drug-induced psychoses. Schizophrenia Bulletin, 16, 97–110.

    Google Scholar 

  • Magliozzi, J.R., Kanter, S.L., Csernansky, J.G., & Hollister, L.E. (1983). Detection of marij use in psychiatric patients by determination of urinary delta-9-tetrahydrocannabino-11-oic acid. Journal of Nervous and Mental Disease, 171, 246–249.

    Google Scholar 

  • Mayfield, D., McCleod, G., & Hall, P. (1974). The CAGE questionnaire: Validation of a new alcoholism screening questionnaire. American Journal of Psychiatry, 131, 1121–1123.

    Google Scholar 

  • McHugo, G.J., Paskus, T.S., & Drake, R.E. (Submitted). Detection of alcoholism in schizophrenia using the MAST. Alcoholism: Clinical and Experimental Research.

  • McLellan, A.T., Luborsky, L., Cacciola, J., Griffith, J., Evans, F., Barr, H.L., & O'Brien, C.P. (1985). New data from the Addiction Severity Index: Reliability and validity in three centers. Journal of Nervous and Mental Disease, 173, 412–423.

    Google Scholar 

  • McLellan, A.T., Luborsky, L., O'Brien, C.P., & Woody, G. (1980). An improved evaluation instrument for substance abuse patients: The Addiction Severity Index. Journal of Nervous and Mental Disease, 168, 26–33.

    Google Scholar 

  • Miller, N.S., & Ries, R.K. (1991). Drug and alcohol dependence and psychiatric populations: The need for diagnosis, intervention, and training. Comprehensive Psychiatry, 32, 268–276.

    Google Scholar 

  • Miller, F.T. & Tanenbaum, J.H. (1989). Drug abuse in schizophrenia. Hospital and Community Psychiatry 40: 849–851.

    Google Scholar 

  • Minkoff, K. & Drake, R.E. (1991). Dual diagnosis of major mental illness and substance disorder. San Francisco: Jossey-Bass.

    Google Scholar 

  • Mueser, K.T., Yarnold, P.R., Levinson, D.F., Singh, H., Bellack, A.S., Kee, K., Morrison, R.L., & Yadalam, K.G. (1990). Prevalence of substance abuse in schizophrenia: Demographic and clinical correlates. Schizophrenia Bulletin, 16, 31–56.

    Google Scholar 

  • Negrete, J.C. & Knapp, W.P. (1986). The effects of cannabis use on the clinical conditions of schizophrenics. Harris, L.S. (ed.) Problems of Drug Dependence. In NIDA Research Monographs 67, Rockville, Md., 321–327.

  • National Institute on Alcohol Abuse and Alcoholism. (1991). Synopses of Cooperative Agreements for Research Demonstration Projects on Alcohol and Other Drug Abuse Treatment for Homeless Persons. Rockville, MD: U.S. Department of Health and Human Services.

    Google Scholar 

  • Noordsy, D.L., Drake, R.E., Teague, G.B., Osher, F.C., Hurlbut, S.C., Beaudett, M.S., & Paskus, T.S. (1991). Subjective experiences related to alcohol use among schizophrenics. Journal of Nervous and Mental Disease, 179, 410–414.

    Google Scholar 

  • O'Farrell, T.H. & Maisto, S.A. (1987). The utility of self report and biological measures of self report in alcoholism treatment outcome studies. Advances in Behavior Research and Therapy, 9, 91–125.

    Google Scholar 

  • Osher, F.C. & Kofoed, L.L. (1989). Treatment of patients with both psychiatric and psychoactive substance use disorders. Hospital and Community Psychiatry, 40, 1025–1030.

    Google Scholar 

  • Oxman, T.E., Rosenberg, D.S., Schnurr, P.P., Tucker, G. & Gala, G. (1988). The language of altered states. Journal of Nervous and Mental Disease, 176, 401–408.

    Google Scholar 

  • Pokorny, A.D. (1965). The multiple readmission psychiatric patient. Psychiatric Quarterly, 39, 70–78.

    Google Scholar 

  • Regier, D.A., Myers, J.K., Kramer, M., Robins, L.N., Blazer, D.G., Hough, R.L., Eaton, W.W., & Locke, B.Z. (1984). The NIMH Epidemiologic Catchment Area Program. Archives of General Psychiatry, 41, 934–941.

    Google Scholar 

  • Regier, D.A., Farmer, M.E., Rae, D.S., Locke, B.Z., Keith, S.J., Judd, L.L., & Goodwin, F.K. (1990). Comorbidity of mental disorders with alcohol and other drug abuse: Results from the Epidemiologic Catchment Area (ECA) Study. Journal of the American Medical Association. 21, 2511–2518.

    Google Scholar 

  • Reich, T., Cloninger, C.R., Van Eerdewegh, P., Rice, J.P., & Mullaney, J. (1988). Secular trends in the familial transmission of alcoholism. Alcoholism: Clinical and Experimental Research, 12, 458–464.

    Google Scholar 

  • Richard, M.L., Liskow, B.I., & Perry, P.J. (1985). Recent psychostimulant use in hospitalized schizophrenics. Journal Clinical Psychiatry, 46, 79–83.

    Google Scholar 

  • Ridgely, M.S., Osher, F.C., & Talbott, S.A. (1987). Chronically Mentally Ill Young Adults with Substance Abuse Problems: Treatment and Training Issues. Rockville, MD: Alcohol, Drug Abuse, and Mental Health Administration.

    Google Scholar 

  • Ries, R.K. & Ellingson, T. (1989). A pilot assessment at one month of 17 dual diagnosis patients. Hospital and Community Psychiatry, 41, 1230–1233.

    Google Scholar 

  • Ries, R.K. & Samson, H. (1987). Substance abuse among inpatient psychiatric patients: clinical and training issues. Substance Abuse, 8, 28–34.

    Google Scholar 

  • Robins, L.N., Helzer, J.E., Croughan, J., & Ratcliff, K. (1981). National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics and validity. Archives of General Psychiatry, 38, 381–389.

    Google Scholar 

  • Robins, L.N., Wing, J., Wittchen, H.U., Helzer, J.E., Babor, T.F., Burke, J., Farmer, A., Jablensky, A., Pickens, R., Regier, D.A., Sartorius, N., & Towle, L.H. (1989). The Composite International Diagnostic Interview: An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Archives of General Psychiatry, 45, 1069–1077.

    Google Scholar 

  • Robinson, A.E. & Wolkind, S.N. (1970). Amphetamine abuse amongst psychiatric inpatients: the use of gas chromatography. British Journal of Psychiatry, 16, 653–644.

    Google Scholar 

  • Rosenberg, S.R., Wolford, G., Drake, R.E., & Oxman, T.E. (In preparation). Language and personality correlates of alcohol use disorder in psychiatric patients.

  • Russel, M., Martier, S.S., Sokol, R.J., Jacobson, S., Jacobson, J., & Bottoms, S. (1991). Screening for pregnancy risk-drinking: TWEAKING the tests. Alcoholism: Clinical and Experimental Research, 15, 368.

    Google Scholar 

  • Ryglewicz, H. (1991). Psychoeducation for clients and families: A way in, out, and through in working with people with dual disorders. Psychosocial Rehabilitation Journal, 15, 79–89.

    Google Scholar 

  • Safer, D.J. (1987). Substance abuse by young adult chronic patients. Hospital and Community Psychiatry, 38, 511–514.

    Google Scholar 

  • Schneier, F.R. & Siris, S.G. (1987). A review of psychoactive substance use and abuse in schizophrenia: Patterns of drug choice. Journal Nervous and Mental Disease, 175, 641–652.

    Google Scholar 

  • Searles, J.S., Alterman, A.I., & Purtill, J.J. (1990). The detection of alcoholism in hospitalized schizophrenics: A comparison of the MAST and the MAC. Alcoholism: Clinical and Experimental Research, 14, 557–560.

    Google Scholar 

  • Selzer, M.L. (1971). The Michigan Alcoholism Screening Test: The quest for a new diagnostic instrument. American Journal of Psychiatry, 127, 89–94.

    Google Scholar 

  • Sevy, S., Kay, S.R., Opler, L.A., & Van Praag, H.M. (1990). Significance of cocaine history in schizophrenia. Journal of Nervous and Mental Disease, 178, 642–648.

    Google Scholar 

  • Skinner, H., Holt, S., Sheu, W.J., & Israel, Y. (1986). Clinical versus laboratory detection of alcohol abuse: the alcohol clinical index: British Medical Journal, 292, 2261–2265.

    Google Scholar 

  • Skinner, H.A. & Sheu, W.J. (1982). Reliability of alcohol use indices: Lifetime drinking history and the MAST. Journal of Studies on Alcohol, 42, 1157–1170.

    Google Scholar 

  • Smith, C.M. & Pristach, C.A. (1990). Utility of the self-administered alcoholism screening test (SAAST) in schizophrenic patients. Alcoholism: Clinical and Experimental Research, 14, 690–694.

    Google Scholar 

  • Spitzer, R.L., Williams, J.B.W., Gibbon, M., & First, M.D. (1988). Structured Clinical Interview for DSM-III-R: Patient Version (SCID-P). New York: Biometrics Research Department, New York State Psychiatric Institute.

    Google Scholar 

  • Stone, A., Greenstein, R., Gamble, G., & McLellan, A.T. Cocaine use in chronic schizophrenic outpatients receiving depot neuroleptic medications. Hospital and Community Psychiatry. In press.

  • Teague, G.B., & Drake, R.E. (1990). Mental health services research through a public-academic liaison: A comparison of two case management models. Proceedings of the First Annual Conference of the National Association of State Mental Health Program Directors Research Institute. Arlington, VA: NASMHPD.

    Google Scholar 

  • Teague, G.B., Schwab, B., & Drake, R.E. (1990). Evaluating Services for Young Adults with Severe Mental Illness and Substance Use Disorders. Arlington, VA: National Association of State Mental Health Program Directors.

    Google Scholar 

  • Test, M.A., Wallisch, L.S., Allness, D.J., & Ripp, K. (1989). Substance use in young adults with schizophrenic disorders. Schizophrenia Bulletin, 15, 465–476.

    Google Scholar 

  • Toland, A.M. & Moss, H.B. (1989). Identification of the alcoholic schizophrenic: Use of clinical laboratory tests and the MAST. Journal Studies on Alcohol, 50, 49–53.

    Google Scholar 

  • Toner, B.B., Gillies, L.A., Prendergast, P., Cote, F., & Browne, C. (1992). Pattern of substance use disorder in the chronically mentally ill. Hospital and community Psychiatry, 43, 251–254.

    Google Scholar 

  • Treffert, D.A. (1978). Marijuana use in schizophrenia: A clear hazard, American Journal of Psychiatry, 135, 1213–1215.

    Google Scholar 

  • West, A., Martindale, C., Hines, D., & Rath, W.T. (1983). Marijuana-induced primary process content in the TAT. Journal of Personality Assessment, 47, 466–467.

    Google Scholar 

  • Yesavage, J.A. & Zarcone, V. (1983). History of drug abuse and dangerous behavior in inpatient schizophrenics. Journal of Clinical Psychiatry, 44, 259–261.

    Google Scholar 

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This work was supported in part by a National Institute of Mental Health Level II Research Scientist Development Award, K02-MH-00839.

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Drake, R.E., Alterman, A.I. & Rosenberg, S.R. Detection of substance use disorders in severely mentally ill patients. Community Ment Health J 29, 175–192 (1993). https://doi.org/10.1007/BF00756343

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