Summary
Seven asthmatic patients were given a single placebo tablet in a first test session and then in two subsequent double blind sessions they randomly received 400 mg bevantolol or 100 mg atenolol, with at least 2 days between each of the sessions. Neither beta-blocker had any significant effect on FVC as compared to the placebo. FEV 1, however, was significantly lower 2 and 3 h after atenolol or bevantolol; there was no significant difference between the effects of the two drugs on FEV 1. Peak expiratory flow rate was reduced by bevantolol but not by atenolol, the difference reaching significance after 3 h. Fenoterol inhalation at the end of each test session always enhanced pulmonary performance, but to a lesser extent after bevantolol than after placebo or atenolol. A slower heart rate was recorded 2, 3, and 4 h after bevantolol and 3 and 4 h after atenolol; the mean 2-h value was significantly lower with atenolol than with bevantolol. No patient suffered any adverse effect. Bevantolol may be slightly less selective than atenolol.
Similar content being viewed by others
References
Bolt W, Cara M, Coppee G, Houberechts A, Lavenne F, Sadoul P, Sartorelli E, Zorn O, avec la collaboration de Jouasset D (1961) Aide mé;moire pour la pratique de l'examen de la fonction ventilatoire par la spirographie établi à la demande de la commission de normalisation des épreuves respiratoires de la haute autorité de la CECA, Coll Hyg Med Trav, Luxembourg 2: 79
Decalmer PBS, Chatterjee SS, Cruickshank JM, Benson MK, Sterling GM (1978) Beta-blockers and asthma. Br Heart J 40: 184–189
Dorow P (1982) Influence of intrinsic sympathomimetic activity (ISA) during beta-adrenoreceptor blockade in asthmatics. Br J Clin Pharmacol 13 [2]: 321–323
Fitzgerald JD, Ruffin R, Smetstad KG, Roberts R, McAinsh J (1978) Studies on the pharmacokinetics and pharmacodynamics of Atenolol in man. Eur J Clin Pharmacol 13: 81–89
Fletcher CM, Pride NB (1984) Definition of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 years on from the Ciba symposium, Thorax 39: 81–85
Greefhorst APM, van Herwaarden CL (1981) comparative study of the ventilatory effects of three beta1-selective blocking agents in asthmatic patients. Eur J Clin Pharmacol 20: 417–421
Gregg I, Nunn AJ (1973) Peak expiratory flow in normal subjects. Br Med J 3: 282
Kofi Ekue JM, Shanks RG, Walsh MJ (1974) Observations on the effect of Beta-adrenoreceptor blocking drug on glyceryl trinitrate tachycardia. Br J Clin Pharmacol 1: 19–26
Louis TA, Lavori PW, Bailar JC, Polansky MM (1984) Crossover and self-controlled designs in clinical research. N Engl J Med 310: 24–31
Mackay AD, Gribbin HR, Baldwin CI, Tattersfield AE (1981) Assessment of bronchial beta-blockade after oral bevantolol. Clin Pharmacol Ther 29: 1–5
Opie LH (1980) Drugs and the Heart. Lancet 1: 693–698
Patakas D, Argiropoulou V, Louridas G, Tsara V (1983) Beta-blockers in bronchial asthma: Effect of propanolol and pindolol on large and small airways. Thorax 38: 108–112
Perks W, Chatterjee S, Croxson R, Cruckshank JM (1978) Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction. Br J Clin Pharmacol 5: 101–106
Ruffin RE, McIntyre EL, Latimer KM, Ward HE, Crockett AJ, Alpers JH (1982) Assessment of beta-adrenoreceptor antagonists in asthmatic patients. Br J Clin Pharmacol 13 [Suppl 2]: 325–335
Skinner C, Palmer KNV, Kerridge DF (1975) Comparison of the effects of acebutolol (Sectral) and practocol (Eraldin) on airways obstruction in asthmatics. Br J Clin Pharmacol 2: 417–422
Taylor SH (1983) Intrinsic sympathomimetic activity: Clinical fact or fiction? Am J Cardiol 52: 16–26
Van Herwaarden CL (1983) Beta-adrenoreceptor blockade and pulmonary function in patients suffering from chronic obstructive lung disease. J Cardiovasc Pharmacol 5 [1]: 46–50
Whitsett TL, Levin DC, Manion CV (1982) Comparison of the beta1- and beta2-adrenoreceptor blocking properties of acebutolol and propanolol. Chest 82: 668–673
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Philip-Joet, F., Saadjian, A., Bruguerolle, B. et al. Comparative study of the respiratory effects of two beta1-selective blocking agents atenolol and bevantolol in asthmatic patients. Eur J Clin Pharmacol 30, 13–16 (1986). https://doi.org/10.1007/BF00614188
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00614188