Summary
The efficacy of a 5% solution of para-aminobenzoic acid (PABA) to protect against photocarcinogenesis was tested in 6 groups, each of which contained 30 light pigmented hairless mice. The light source was a Phillips TL 40 W/12, which mainly emits UVB. PABA significantly retarded the tumor induction time (p<0.05) and reduced both tumor yield and carcinoma yield (p<0.05). The dorsal skin of the mice was removed and weighed. The mean weight of UVR-exposed mice skin protected with PABA did not differ from that of the controls, but in the non-protected UVR-exposed mice the skin samples were significantly heavier (p<0.05).
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Flindt-Hansen, H., Thune, P. & Eeg Larsen, T. The inhibiting effect of PABA on photocarcinogenesis. Arch Dermatol Res 282, 38–41 (1990). https://doi.org/10.1007/BF00505643
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DOI: https://doi.org/10.1007/BF00505643