Abstract
The intravenous toxicity to the rat of 36 pyrethroids has been examined. With two exceptions they cause either (1) T-syndrome, consisting of aggressive sparring, sensitivity to external stimuli, fine progressing to gross whole body tremor and prostration or (2) CS-syndrome, consisting of pawing and burrowing behaviour, salivation, coarse tremor, progressing to sinuous writhing (choreoathetosis) and clonic seizures. The two exceptions presented a TS-syndrome with salivation associated with the T-syndrome. No clearcut relationship between chemical structure and symptoms of poisoning has emerged through some generalisations are discussed.
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References
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Verschoyle, R.D., Aldridge, W.N. Structure-activity relationships of some pyrethroids in rats. Arch. Toxicol. 45, 325–329 (1980). https://doi.org/10.1007/BF00293813
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DOI: https://doi.org/10.1007/BF00293813