Summary
In laboratory studies using albino house mice, a female's prior intrauterine position can affect many postnatal physiological, morphological and behavioral characteristics. Females flanked by males in utero (2M females) exhibit more aggressive dominance than females flanked by females (OM females). Thus, wild 2M females may be most successful during peak population densities when their aggressive nature would allow them to displace other females from limited resources. 2M and 0M females and males delivered by cesarean section were individually marked and released as young adults on two occasions onto a “highway island” (the area enclosed by exit and entrance ramps at an interchange) to determine whether 2 M females have a competitive advantage over 0 M females in the field. Males were included to create realistic population structure; their intrauterine position was not a treatment. Feeding stations afforded individuals an opportunity to exhibit their dominance by maintaining home-ranges at or near the stations. The populations were monitored by periodic live-trapping and reproductive success was determined using field body weights and by post-mortem examination for uterine implantation scars. Survival and capture rates were estimated, using a modified Jolly-Seber markrecapture program, for each of four intervals between trapping occasions over the course of 7 weeks. There were no overall differences in survivorship between 2M and 0M females, neither type of female was caught more frequently at feeding stations and they did not differ in measures of reproductive success. However, 2M females had significantly larger home-range sizes than 0M females and thus space use may be a trait “masculinized” by prior intrauterine position. Although there are a number of life-history characteristics that differ between 0M and 2M females in the laboratory that we did not test specifically in the field, our findings and other features of wild house mouse biology suggest that prior intrauterine position does not have a strong effect on survival and reproduction in the wild.
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References
Allen TO, Haggett BN (1977) Group housing of pregnant mice reduces copulatory receptivity of female progeny. Physiol Behav 19:61–68
Berry RJ, Jakobson ME (1971) Life and death in an island population of the house mouse. J Gerontol 6:187–197
Bujalska G (1973) The role of spacing behaviour among females in the regulation of reproduction in the bank vole. J Reprod Fert, Suppl 19:465–474
Burnham KP, Anderson DR, White GC, Brownie C, Pollock KH (1987) Design and analysis methods for fish survival experiments based on release-recapture. Am Fish Soc Monogr 5. Bethesda
Carpenter FL (1987) Food abundance and territoriality: to defend or not to defend? Am Zool 27:387–400
Clark M, Galef B (1988) Effects of uterine position on rate of sexual development in female Mongolian gerbils. Physiol Behav 42:15–18
Clemens L, Gladue B, Coniglio L (1978) Prenatal endogenous androgenic influences on masculine sexual behavior and genital morphology in male and female rats. Horm Behav 10:40–53
Coppola DM (1986) Reproductive status and the assimilation of introduced females into a wild population of house mice. Acta Ther 31:221–237
Coppola DM, Vandenbergh JG (1987) Induction of a pubery-regulating chemosignal in wild mouse populations. J Mammal 68:86–91
Davis DE, Emlen JT Jr (1948) The placental scar as a measure of fertility. J Wildl Manage 12:162–166
DeLong KT (1967) Population ecology of feral house mice. Ecology 48:611–634
Gupta C, Goldman AS (1986) The arachidonic acid cascade is involved in the masculinizing action of testosterone on embryonic external genitalia in mice. Proc Natl Acad Sci 83:4346–4349
Harestad AS, Bunnell FL (1979) Home range and body weight-a reevaluation. Ecology 60:389–402
Houtsmuller EJ, Slob AK (1990) Masculinization and defeminization of female rats by males located caudally in the uterus. Physiol Behav 48:555–560]
Ims RA (1987) Determinants of competitive success in Clethrionomys rufocanus. Ecology 68:1812–1818
Ims RA (1988) Spatial clumping of sexually receptive females induces space sharing among male voles. Nature 335:541–543
Ims RA (1990) Determinants of natal dispersal and space use in grey-sided voles, Clethrionomys rufocanus: a combined field and laboratory experiment. Oikos 57:106–113
Jolly GM (1965) Explicit estimates from capture-recapture data with both death and immigration-stochastic model. Biometrika 52:225–247
Keever C (1950) Causes of succession on old-fields of the Piedmont, North Carolina. Ecol Monogr 20:229–250
Kirkpatrick RL (1980) Physiological indices in wildlife management. In: Schemnitz SD (ed) Wildlife management techniques manual. The Wildlife Society, Washington DC, pp 99–112
Krementz DG, Nichols JD, Hines JE (1989) Postfledging survival of European starlings. Ecology 70:646–655
Lidicker WZ (1966) Ecological observations on a feral house mouse population declining to extinction. Ecol Monogr 36:27–50
Massey A (1982) Ecology of house mouse populations confined by highways. J Elisha Mitchell Sci Soc 98:135–143
Massey A, Vandenbergh JG (1980) Puberty delay by a urinary cue from female mice in feral populations. Science 209:821–822
Meisel R, Ward I (1981) Fetal female rats are masculinized by male littermates located caudally in the uterus. Science 213:239–242
Ostfeld RS (1986) Territoriality and mating system of California voles. J Anim Ecol 55:691–706
Perrigo G, Bronson FH (1985) Behavioral and physiological responses of female house mice to foraging variation. Physiol Behav 34:437–440
Politch J, Herrenkohl L (1984) Effects of prenatal stress on reproduction in male and female mice. Physiol Behav 32:95–99
Rines JP, vom Saal FS (1984) Fetal effects on sexual behavior and aggression in young and old female mice treated with estrogen and progesterone. Horm Behav 18:117–129
Rowe FP, Taylor EJ, Chudley AHJ (1963) The effect of crowding on the reproduction of the house-mouse (Mus musculus L.) living in corn-ricks. J Anim Ecol 33:477–483
Rugh R (1968) The mouse: Its reproduction and development. Burgess, Minneapolis
Salvioni M (1988) Home range and social behavior of three species of European Pitymys (Mammalia, Rodentia). Behav Ecol Sociobiol 22:203–210
Scher GAF (1965) A note on the multiple-recapture census. Biometrika 52:254–259
Smith WW (1954) Reproduction in the house mouse, Mus musculus L., in Mississippi. J Mammal 35:509–515
Southwick CH (1958) Population characteristics of house mice living in English earn ticks: density relationships. Proc Zool Soc London 131:163–175
Stueck KL, Barrett GW (1978) Effects of resource partitioning on the population dynamics and energy utilization strategies of feral house mice (Mus musculus) populations under experimental field conditions. Ecology 59:539–551
Stüwe M, Blohowiak CE (1982) Microcomputer programs for the analysis of animal locations (MCPAAL). Conservation and Research Center, Nat Zool Park, Smithsonian Inst. Unpub Mimeo
Vomachka A, Lisk R (1986) Androgen and estrogen levels in plasma and amniotic fluid of lat gestational male and female hamsters: Uterine position effects. Horm Behav 20:181–193
vom Saul F (1981) Variation in phenotype due to random intrauterine positioning of male and female fetuses in rodents. J Reprod Fertil 62:633–650
vom Saul F (1984) The intrauterine position phenomenon: effects on physiology, aggressive behavior, and population dynamics in house mice. In: Flannely K, Blanchard R, Blanchard D (eds) Biological Perspectives on Aggression. Alan Liss Inc, New York, pp 135–179
vom Saul F (1989) Sexual differentiation in litter-bearing mammals: Influence of sex of adjacent fetuses in utero. J Anim Sci 67:1824–1840
vom Saal F, Bronson F (1978) In utero proximity of female house mouse fetuses to males: Effect on reproductive performance during later life. Biol Reprod 19:842–853
vom Saal F, Bronson F (1980) Sexual characteristics of adult female mice are correlated with their blood testosterone levels during prenatal development. Science 208:597–599
vom Saal F, Moyer C (1985) Prenatal effects on reproductive capacity during aging in female mice. Biol Reprod 32:1116
vom Saal F, Dhar M, Even M (1989) Uterine blood flow, intrauterine transport of steroids, and the intrauterine position phenomenon in rats. Abstract. Conf of Reprod Behav Skidmore College, Saratoga Springs, N.Y., p. 21
vom Saal F, Quadagno DM, Even MD, Keisler LW, Keisler DH, Khan S (1990) Paradoxical effects of maternal stress on fetal steroids and postnatal reproductive traits in female mice from different intrauterine positions. Biol Reprod 43:751–761
Ward IL, Weisz J (1980) Maternal stress alters plasma testosterone in fetal males. Science 207:328–329
Zielinski WJ, Vandenbergh JG (1991) The effect of intrauterine position and social density on age of first reproduction in wildtype female house mice (Mus musculus). J Comp Psych 105:134–139
Zielinski WJ, Vandenbergh JG (1991) Increased survivorship of testosterone-treated female house mice (Mus musculus) in high-density field conditions. Anim Behav 42:955–967
Zielinski WJ, Vandenbergh JG, Montano MM (1991) Effects of social stress and intrauterine position on sexual phenotype in wild-type house mice (Mus musculus). Physiol Behav 49:117–123
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Zielinski, W.J., vom Saal, F.S. & Vandenbergh, J.G. The effect of intrauterine position on the survival, reproduction and home range size of female house mice (Mus musculus). Behav Ecol Sociobiol 30, 185–191 (1992). https://doi.org/10.1007/BF00166702
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DOI: https://doi.org/10.1007/BF00166702