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A case-control study of major congenital heart defects in Sweden — 1981–1986

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Abstract

This paper reports the results of a case-control study of major congenital heart defects (CHD) in Sweden. During the period 1981–1986, 1,324 such cases were identified and 2,648 controls were selected. Some common maternal characteristics and exposures were studied using information from prospectively collected data. Possible associations with CHD were found for previous perinatal death, maternal diabetes, epilepsy, hydramnios and disproportion between fetus and pelvis. More specific associations were observed between previous spontaneous abortion, epilepsy, hydramnios and truncus anomalies and between diabetes and septal anomalies. However, no associations were found with involuntary childlessness, contraceptive use, or smoking.

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Abbreviations

ASD:

atrial septal defect

CHD:

congenital heart defect

CI:

confidence interval

CoA:

coarctation of the aorta

DORY:

double outlet right ventricle

ECD:

endocardial cushion defect

HLHS:

hypoplastic left heart syndrome

IUD:

intrauterine device

LMP:

last menstrual period

OC:

oral contraceptive

OR:

odds ratio

PDA:

patent ductus arteriosus

TGV:

transposition of the great vessels

VSD:

ventricular septal defect

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  1. Department of Embryology, University of Lund, Biskopsgatan 7, S-223 62, Lund, Sweden

    P. Pradat

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Pradat, P. A case-control study of major congenital heart defects in Sweden — 1981–1986. Eur J Epidemiol 8, 789–796 (1992). https://doi.org/10.1007/BF00145321

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