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Implications of intermediate filament protein phosphorylation

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Summary

Intermediate filament (IF) proteins, a large family of tissue specific proteins, undergo several posttranslational modifications, with phosphorylation being the most studied modification. IF protein phosphorylation is highly dynamic and involves the head and/or tail domains of these proteins, which are the domains that impart most of the structural heterogeneity and hence presumed tissue specific functions. Although the function of IF proteins remains poorly understood, several regulatory roles for IF protein phosphorylation have been identified or are emerging. Those roles include filament disassembly and reorganization, solubility, localization within specific cellular domains, association with other cytoplasmic or membrane associated proteins, protection against physiologic stress and mediation of tissue-specific functions. Understanding the mechanistic and functional aspects of IF protein phosphorylation is providing insights not only regarding the function of this modification, but also regarding the function of IF proteins.

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  1. Chih-Fong Chou

    Present address: Institute of Molecular and Cell Biology, National University of Singapore, 0511, Singapore

Authors and Affiliations

  1. VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA

    Nam-On Ku, Jian Liao, Chih-Fong Chou & M. Bishr Omary

  2. Digestive Disease Center, Stanford University School of Medicine, Stanford

    Nam-On Ku, Jian Liao, Chih-Fong Chou & M. Bishr Omary

Authors
  1. Nam-On Ku
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  2. Jian Liao
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  3. Chih-Fong Chou
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  4. M. Bishr Omary
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Ku, NO., Liao, J., Chou, CF. et al. Implications of intermediate filament protein phosphorylation. Cancer Metast Rev 15, 429–444 (1996). https://doi.org/10.1007/BF00054011

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