Overview
- Nominated as an outstanding PhD thesis by Peking University
- Reports on important progress in the study of stabilized peptide drugs
- Introduces applications in cancer stem cell therapy and self-assembly for novel nanomaterials
- Includes a diversity-oriented synthesis methodology for constructing stabilized peptides and a clear study of the correlation between peptides’ structure and their biophysical/biochemical properties
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (4 chapters)
Keywords
About this book
This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.
Authors and Affiliations
Bibliographic Information
Book Title: Development of In-Tether Carbon Chiral Center-Induced Helical Peptide
Book Subtitle: Methodology and Applications
Authors: Kuan Hu
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-981-33-6613-8
Publisher: Springer Singapore
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2021
Hardcover ISBN: 978-981-33-6612-1Published: 27 January 2021
Softcover ISBN: 978-981-33-6615-2Published: 27 January 2022
eBook ISBN: 978-981-33-6613-8Published: 26 January 2021
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XV, 102
Number of Illustrations: 10 b/w illustrations, 65 illustrations in colour
Topics: Bioorganic Chemistry, Protein-Ligand Interactions, Biomaterials, Biochemical Engineering, Cancer Research