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Host-Parasite Cellular and Molecular Interactions in Protozoal Infections

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. K.-P. Chang

    1. Department of Microbiology and Immunology, UHS/Chicago Medical School, North Chicago, USA

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  2. David Snary

    1. Department of Molecular Biology, Wellcome Research Laboratories, Beckenham, Kent, England

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Nato ASI Subseries H: (ASIH, volume 11)

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Table of contents (48 papers)

  1. Front Matter

    Pages I-XIX
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  2. Trypanosoma

    1. Pattern of Variant Surface Glycoprotein Coating in Nascent Metacyclic Trypanosoma Brucei in the Salivary Glands of Glossina Morsitans

      • K. Vickerman, L. Tetley, C. M. R. Turner, J. D. Barry
      Pages 1-8

    2. Evolution of Antigenic Variation in African Trypanosomes

      • John C. Boothroyd, Thomas P. Beals
      Pages 9-18

    3. Structural Studies on the Glycophospholipid Membrane Anchor of Trypanosoma Brucei Variant Surface Glycoprotein

      • M. A. J. Ferguson, R. A. Dwek, S. W. Homans, T. W. Rademacher
      Pages 19-28

    4. Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids

      • Alan H. Fairlamb, Graeme B. Henderson
      Pages 29-40

    5. Differentiation of Trypanosoma brucei from Bloodstream to Procyclic Trypomastigotes

      • Peter Overath, Roland Bülow, Joachim Czichos, Bernhard Ehlers
      Pages 41-49

    6. Digestive Enzymes, Receptor-Mediated Endocytosis and Their Role in the Nutrition of the Bloodstream-Form Trypanosome

      • Fred R. Opperdoes, Isabelle Coppens, Pierre Baudhuin
      Pages 51-65

    7. The Cytoskeleton of Trypanosoma Brucei: Genes and Proteins

      • R. Braun, T. Seebeck, K. Behrens, M. Imboden, A. Schneider, V. Küng
      Pages 67-72

    8. Genetic Re-Assortment of African Trypanosomes in Glossina

      • L. Jenni, R. Brun
      Pages 73-78

    9. Cell Surface Glycoproteins of Trypanosoma Cruzi

      • David Snary, Michael A. J. Ferguson, Anthony K. Allen, Michael A. Miles, Alan Sher
      Pages 79-87

    10. A Specific Inhibitor of Trypanosoma Cruzi Neuraminidase Found in Human Plasma

      • R. P. Prioli, I. Rosenberg, M. E. A. Pereira
      Pages 89-95

    11. Definition of Trypanosoma Cruzi Antigens by Antibodies and T Cells

      • L. Hudson, F. Guhl
      Pages 97-105

  3. Leishmania

    1. Molecular Pathogenicity of Leishmania in Intracellular Parasitism of Macrophages: Association of Virulent Phenotype with Increased Expression of a Major Membrane Glycoprotein and Microsomal N-Acetylglucosaminyl-Transferase

      • K.-P. Chang, J. A. Kink
      Pages 107-116

    2. Infectivity of Leishmania Promastigotes is Dependent on the Expression of a 65,000 Dalton Surface Antigen

      • F. Santoro, M. Kweider, J. L. Lemesre, F. Darcy, F. S. Rizvi
      Pages 117-122

    3. Characterization of Developmentally Regulated Molecules of Leishmania

      • D. McMahon-Pratt, C. L. Jaffe, L. Kahl, P. Langer, K. Lohman, A. Pan et al.
      Pages 123-136

    4. Leishmania Antigens Probed by Monoclonal Antibodies to Leishmania Membrane and to Acetylcholine Receptor

      • K. Ph. Soteriadou, A. K. Tzinia, M. G. Hadziantoniou, S. J. Tzartos
      Pages 137-147

    5. Structural Studies on Surface Glycoproteins of Leishmania Promastigotes: Isolation, Amino Acid Composition and Amino Terminal Sequence Studies

      • Robert W. Olafson, Anne E. Wallis, Robert McMaster
      Pages 149-156

    6. Membrane Attachment of the Major Surface Protein of Leishmania Promastigotes

      • C. Bordier, R. Etges, J. Bouvier, J. Ward, M. J. Turner, M. L. Cardoso de Almeida
      Pages 157-163

    7. The Promastigote Surface Protease of Leishmania

      • Robert Etges, Jacques Bouvier, Clement Bordier
      Pages 165-168

    8. Acid Protease Activity of Leishmania gp63 and Its Possible Role in Virulence

      • Gautam Chaudhuri, K. -P. Chang
      Pages 169-173
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Keywords

About this book

Tropical diseases such as leishmaniasis, malaria. trypanosomiasis, toxoplasmosis and amebiasis continue to plague the world, resulting in considerable morbidity and mortality, especially in the third world countries. These diseases are caused by a group of protozoa which have, over the years, undergone evolutionary adaptation to live often intracellularly in a parasitic way of life. So well-adapted have they become that they recognize the right hosts or cells to parasitize, yet at the same time they escape recognition and destruction by the host immune system. The mechanisms of such recognition and the escape of recognition are governed largely by host-parasite surface membrane interactions at the cellular and molecular level. Unique molecules produced by unusual pathways of these parasites have also been discovered and found to play important roles in their survival in the host. Understanding these mechanisms and pathways is essential not only to formulate a rational strategy for chemo- and immuno-prophylaxis and -therapy but also to unravel the mystery of biological evolution in symbiosis and parasitism. In the advent of our knowledge on the molecular biology and biochemistry of parasite membrane and other molecules, it is opportune to examine and discuss their possible roles in host-parasite recognition and interaction in a comparative approach. To highlight the recent advances of this area in various host-parasite systems, a NATO advanced Research Workshop was held from September 27 to October 1, 1986 at Hotel Villa del Mare, Acquafredda di Maratea, Italy.

Editors and Affiliations

  • Department of Microbiology and Immunology, UHS/Chicago Medical School, North Chicago, USA

    K.-P. Chang

  • Department of Molecular Biology, Wellcome Research Laboratories, Beckenham, Kent, England

    David Snary

Bibliographic Information

  • Book Title: Host-Parasite Cellular and Molecular Interactions in Protozoal Infections

  • Editors: K.-P. Chang, David Snary

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-72840-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-642-72842-6Published: 12 February 2012

  • eBook ISBN: 978-3-642-72840-2Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: XIX, 425

  • Topics: Cell Biology, Virology

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