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Leukocyte Integrins in the Immune System and Malignant Disease

  • Book
  • © 1998

Overview

Editors:
  1. Bernhard Holzmann

    1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany

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  2. Hermann Wagner

    1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • The book focuses on leukocyte integrins, in particular, on receptors of the alpha4 subfamily.

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 231)

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Table of contents (10 chapters)

  1. Front Matter

    Pages I-VII
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  2. VLA-4-Mediated Signaling

    • C. Morimoto, S. Iwata, K. Tachibana
    Pages 1-22

  3. Functions of α4- and β7-Integrins in Hematopoiesis, Lymphocyte Trafficking and Organ Development

    • N. Wagner, W. Müller
    Pages 23-32

  4. Regulation of Integrin Function by Inside-Out Signaling Mechanisms

    • W. Kolanus, L. Zeitlmann
    Pages 33-49

  5. The Role of α4-Integrin in T Lymphocyte Migration Into the Inflamed and Noninflamed Central Nervous System

    • B. Engelhardt
    Pages 51-64

  6. The Roles of α4-Integrins in the Development of Insulin-Dependent Diabetes Mellitus

    • S. A. Michie, H.-K. Sytwu, J. O. McDevitt, X.-D. Yang
    Pages 65-83

  7. Immunosuppression by Blocking α4-Integrins/VCAM-1 Adhesion

    • M. Isobe, J. Hori, J. Suzuki
    Pages 85-98

  8. Virus-Induced T Cell Activation and the Inflammatory Response

    • A. R. Thomsen, A. Nansen, J. P. Christensen
    Pages 99-123

  9. α4 Integrins and Tumor Metastasis

    • B. Holzmann, U. Gosslar, M. Bittner
    Pages 125-141

  10. Organ-Specific Requirements for Cell Adhesion Molecules During Lymphoma Cell Dissemination

    • D. Naor, R. Vogt Sionov, M. Zahalka, M. Rochman, B. Holzmann, D. Ish-Shalom
    Pages 143-166

  11. The Ups and Downs of α2β1-Integrin Expression: Contributions to Epithelial Cell Differentiation and the Malignant Phenotype

    • M. M. Zutter, S. A. Santoro
    Pages 167-185

  12. Back Matter

    Pages 187-192
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Keywords

About this book

Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (MACKAY et al. 1990). An important feature of this migration is the ability of lymphocytes to recognize and adhere to the surface of blood vessel endothelial cells before migrating through the vessel wall into surrounding tissue (CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). Adhesion interactions of vascular endothelium with lymphocytes under flow or shear consist of at least four steps: (I) an initial transient sticking or rolling; (2) if the lymphocytes encounter appropriate activating or chemotactic factors in the local environment, rolling may be followed by a lymphocyte activation step that then leads to; (3) strong adhesion or sticking that may be followed by; (4) lym­ phocyte diapedesis into tissue (BUTCHER 1991; SHIMUZU et al. 1992; SPRINGER 1994; BARGATZE et al. 1995). Specific lymphocyte and endothelial adhesion molecules (AM) are involved in each step of this "adhesion cascade" (reviewed in CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). This allows lymphocyte migration to be controlled at several different steps, leading to a combinatorial increase in specificity and sensitivity.

Editors and Affiliations

  • Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany

    Bernhard Holzmann, Hermann Wagner

Bibliographic Information

  • Book Title: Leukocyte Integrins in the Immune System and Malignant Disease

  • Editors: Bernhard Holzmann, Hermann Wagner

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-71987-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1998

  • Softcover ISBN: 978-3-642-71989-9Published: 11 January 2012

  • eBook ISBN: 978-3-642-71987-5Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VIII, 189

  • Topics: Immunology, Cell Biology, Cancer Research

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