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DNA Methylation

Molecular Biology and Biological Significance

  • Book
  • © 1993

Overview

Editors:
  1. Jean-Pierre Jost

    1. Friedrich Miescher-Institut, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  2. Hans-Peter Saluz

    1. IRBM, Pomenzia (Roma), Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Experientia Supplementum (EXS, volume 64)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-ix
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  2. A Chronicle of DNA methylation (1948–1975)

    • Arthur Weissbach
    Pages 1-10

  3. Major techniques to study DNA methylation

    • Hanspeter Saluz, Jean-Pierre Jost
    Pages 11-26

  4. Methylation of cytosine influences the DNA structure

    • Wolfgang Zacharias
    Pages 27-38

  5. Methylation of DNA in Prokaryotes

    • Mario Noyer-Weidner, Thomas A. Trautner
    Pages 39-108

  6. Structure, function and regulation of mammalian DNA methyltransferase

    • Heinrich Leonhardt, Timothy H. Bestor
    Pages 109-119

  7. Regulation of de novo methylation

    • R. L. P. Adams, H. Lindsay, A. Reale, C. Seivwright, S. Kass, M. Cummings et al.
    Pages 120-144

  8. Effect of DNA methylation on the binding of vertebrate and plant proteins to DNA

    • Melanie Ehrlich, Kenneth C. Ehrlich
    Pages 145-168

  9. CpG Islands

    • Francisco Antequera, Adrian Bird
    Pages 169-185

  10. DNA methyltransferases and DNA site-specific endonucleases encoded by chlorella viruses

    • Michael Nelson, Yanping Zhang, James L. Van Etten
    Pages 186-211

  11. Control of DNA methylation in fungi

    • Eric U. Selker
    Pages 212-217

  12. The role of DNA methylation in the regulation of plant gene expression

    • E. J. Finnegan, R. I. S. Brettell, E. S. Dennis
    Pages 218-261

  13. Patterns of de novo DNA methylation and promoter inhibition: Studies on the adenovirus and the human genomes

    • Walter Doerfler
    Pages 262-299

  14. DNA Methylation and retrovirus expression

    • Daniel P. Bednarik
    Pages 300-329

  15. Effect of DNA methylation on dynamic properties of the helix and nuclear protein binding in the H-ras promoter

    • Mack J. Rachal, Paula Holton, Jean-Numa Lapeyre
    Pages 330-342

  16. DNA methylation and embryogenesis

    • Aharon Razin, Howard Cedar
    Pages 343-357

  17. X chromosome inactivation and DNA methylation

    • Judith Singer-Sam, Arthur D. Riggs
    Pages 358-384

  18. DNA methylation: Its possible functional roles in developmental regulation of human globin gene families

    • Chien Chu, C.-K. James Shen
    Pages 385-403

  19. DNA Methylation, chromatin structure and the regulation of gene expression

    • M. Graessmann, A. Graessmann
    Pages 404-424

  20. Steroid hormone dependent changes in DNA methylation and its significance for the activation or silencing of specific genes

    • J. P. Jost, H. P. Saluz
    Pages 425-451
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Keywords

About this book

The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see first chapter). Recognition of its possible physiologi­ cal role in eucaryotes was first suggested in 1964 by Srinivasan and Borek (see first chapter). Since then work in a great many laboratories has established both the ubiquity of 5-methylcytosine and the catholicity of its possible regulatory function. The explosive increase in the number of publications dealing with DNA methylation attests to its importance and makes it impossible to write a comprehensive coverage of the literature within the scope of a general review. Since the publication of the 3 most recent books dealing with the subject (DNA methylation by Razin A. , Cedar H. and Riggs A. D. , 1984 Springer Verlag; Molecular Biology of DNA methylation by Adams R. L. P. and Burdon R. H. , 1985 Springer Verlag; Nucleic Acids Methylation, UCLA Symposium suppl. 128, 1989) considerable progress both in the techniques and results has been made in the field of DNA methylation. Thus we asked several authors to write chapters dealing with aspects of DNA methyla­ tion in which they are experts. This book should be most useful for students, teachers as well as researchers in the field of differentiation and gene regulation. We are most grateful to all our colleagues who were willing to spend much time and effort on the publication of this book. We also want to express our gratitude to Yan Chim Jost for her help in preparing this book.

Editors and Affiliations

  • Friedrich Miescher-Institut, Basel, Switzerland

    Jean-Pierre Jost

  • IRBM, Pomenzia (Roma), Italy

    Hans-Peter Saluz

Bibliographic Information

  • Book Title: DNA Methylation

  • Book Subtitle: Molecular Biology and Biological Significance

  • Editors: Jean-Pierre Jost, Hans-Peter Saluz

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/978-3-0348-9118-9

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Verlag 1993

  • Softcover ISBN: 978-3-0348-9915-4Published: 30 September 2011

  • eBook ISBN: 978-3-0348-9118-9Published: 11 November 2013

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: X, 572

  • Topics: Biochemistry, general, Cell Biology

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