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Targeting of Drugs With Synthetic Systems

  • Book
  • © 1986

Overview

Editors:
  1. Gregory Gregoriadis

    1. Royal Free Hospital School of Medicine, London, England

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  2. Judith Senior

    1. Royal Free Hospital School of Medicine, London, England

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    You can also search for this editor in PubMed   Google Scholar

  3. George Poste

    1. Smith Kline & French Laboratories, Philadelphia, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 113)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Mannose Binding Proteins in the Liver and Blood

    • John A. Summerfield
    Pages 1-12

  3. Cell Membrane Molecules on Neoplastic Cells: Their Role in Malignant Cell Transformation and Dissemination

    • Lennart Olsson, Claus Due
    Pages 13-23

  4. Tumor-Associated Glycolipid Markers: Possible Targets for Drug and Immuno-Toxin Delivery

    • Sen-itiroh Hakomori
    Pages 25-40

  5. Interaction of Macromolecular Drugs with Receptors

    • Josef Pitha
    Pages 41-55

  6. Endocytosis and Lysosomes: Recent Progress in Intracellular Traffic

    • J. B. Lloyd
    Pages 57-63

  7. Peptides as Targets and Carriers

    • P. S. Ringrose, M. J. Humphrey
    Pages 65-86

  8. Hepatic Functions in Health and Disease: Implications in Drug Carrier Use

    • Neil McIntyre
    Pages 87-96

  9. Targeting with Synthetic Polymers: A Realistic Goal

    • J. B. Lloyd
    Pages 97-101

  10. Drug-Poly(Lysine) Conjugates: Their Potential for Chemotherapy and for the Study of Endocytosis

    • Hugues J.-P. Ryser, Wei-Chiang Shen
    Pages 103-121

  11. Targeting of Colloidal Carriers and the Role of Surface Properties

    • S. S. Davis, S. J. Douglas, L. Illum, P. D. E. Jones, E. Mak, R. H. Muller
    Pages 123-146

  12. Targetable Nanoparticles

    • P. Couvreur, V. Lenaerts, A. Ibrahim, L. Grislain, L. Van Snick, P. Guiot et al.
    Pages 147-164

  13. Polymers as Matrices for Drug Release

    • Paolo Ferruti
    Pages 165-182

  14. Liposomes In Vivo: A Relationship between Stability and Clearance?

    • Gregory Gregoriadis, Judith Senior
    Pages 183-192

  15. Liposomes as Drug Carriers to Liver Macrophages: Fundamental and Therapeutic Aspects

    • Frits Roerdink, Joke Regts, Toos Daemen, Irma Bakker-Woudenberg, Gerrit Scherphof
    Pages 193-206

  16. Alternate Delivery of Interferons

    • Deborah A. Eppstein
    Pages 207-219

  17. Liposomes in Antimicrobial Therapy

    • Gabriel Lopez-Berestein, Rudolph L. Juliano, Kapil Mehta, Reeta Mehta, Teresa McQueen, Roy L. Hopfer
    Pages 221-228

  18. Design, Characterization and Anti-Tumor Activity of Adriamycin-Containing Phospholipid Vesicles

    • Alberto Gabizon, Dorit Goren, Avner Ramu, Yechezkel Barenholz
    Pages 229-238

  19. Particle Charge and Surface Hydrophobicity of Colloidal Drug Carriers

    • R. H. Muller, S. S. Davis, L. Illum, E. Mak
    Pages 239-263

  20. Particle Size Analysis of Colloidal Systems by Photon Correlation Spectroscopy

    • S. J. Douglas, S. S. Davis
    Pages 265-276
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Keywords

About this book

Targeting of drugs via carrier systems to sites in the body in need of pharmacologic intervention is a rapidly growing area of research in the treatment or prevention of disease. It has evolved from the need to preferentially deliver drugs, enzymes, vitamins, hormones, antigens, etc. to target cells and organs so as to avoid toxicity, waste of drugs through premature secretion or inactivation and at the same time render treatment more convenient and cost-effective. A wide assortment of naturally occ­ urring or semi-synthetic drug carriers (e. g. antibodies, glycoproteins, lectins, peptide hormones, cells and liposomes), their inter action with relevant receptors and mediation of optimal pharmacological action were discussed in the two previous NATO Advanced Studies Institutes (ASI) of this series, "Targeting of Drugs" and "Receptor-Mediated Targeting of Drugs", the proceedings of wh ich were published by Plenum in 1982 and 1984 respectively. This book contains the proceedings of the 3rd NATO ASI "Targeting of Drugs with Synthetic Systems" held as be fore at Cape Sounion, Greece during 24 June-5 July 1985. It deals mostly with man-made carriers such as a variety of polymers, matrices, liposomes and other colloidal micro­ particles. The twenty chapters discuss the interaction of such carriers with the biological milieu, approaches to bypass the reticuloendothelial system (or, when needed, take advantage of its interception of carriers to optimally deliver drugs to phagocytes) and ways to improve delivery to specific cells, often with the help of carrier-linked ligands.

Editors and Affiliations

  • Royal Free Hospital School of Medicine, London, England

    Gregory Gregoriadis, Judith Senior

  • Smith Kline & French Laboratories, Philadelphia, USA

    George Poste

Bibliographic Information

  • Book Title: Targeting of Drugs With Synthetic Systems

  • Editors: Gregory Gregoriadis, Judith Senior, George Poste

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-5185-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1986

  • Softcover ISBN: 978-1-4684-5187-0Published: 25 November 2012

  • eBook ISBN: 978-1-4684-5185-6Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: 308

  • Number of Illustrations: 50 b/w illustrations

  • Topics: Polymer Sciences

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