Overview
- Editors:
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Thomas W. Clarkson
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University of Rochester School of Medicine, Rochester, USA
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Polly R. Sager
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University of Connecticut Health Center, Farmington, USA
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Tore L. M. Syversen
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University of Trondheim Faculty of Medicine, Trondheim, Norway
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Table of contents (20 chapters)
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Overview
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- Polly R. Sager, Tore L. M. Syversen, Thomas W. Clarkson, John B. Cavanagh, Arnljot Elgsaeter, Hans Cato Guldberg et al.
Pages 3-21
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- Tore L. M. Syversen, Polly R. Sager, Thomas W. Clarkson, John B. Cavanagh, Anljot Elgsaeter, Hans Cato Guldberg et al.
Pages 25-34
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Invited Papers
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Microtubules and Microtubule Inhibitors
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- Susan B. Horwitz, Peter B. Schiff, Jerome Parness, James J. Manfredi, Wilfredo Mellado, Samar N. Roy
Pages 53-65
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- Edward H. Byard, Keith Gull
Pages 83-96
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- Polly R. Sager, Tore L. M. Syversen
Pages 97-116
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Cytoskeleton of the Nervous System
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- Bruce G. Gold, John W. Griffin, Donald L. Price, Paul N. Hoffman
Pages 119-127
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- Pierluigi Gambetti, Salvatore Monaco, Lucila Autilio-Gambetti, Lawrence M. Sayre
Pages 129-142
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- Veli-Pekka Lehto, Ismo Virtanen, Kai Savolainen
Pages 143-158
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- Doyle G. Graham, Gyöngyi Szakàl-Quin, Leslie Milam, Marcia R. Gottfried, D. Carter Anthony
Pages 167-174
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Cytoskeleton and Membrane Related Events
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- Hermann Passow, Melanie Shields, Paul La Celle, Ryszard Grygorczyk, Wolfgang Schwarz, Reiner Peters
Pages 177-186
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- Arnljot Elgsaeter, Arne Mikkelsen, Bjørn T. Stokke
Pages 187-197
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- Vivianne T. Nachmias, Robert M. Leven
Pages 199-211
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- Robin Jones, Michael Sheetz
Pages 213-220
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- Arnold R. Brody, Lila H. Hill, Thomas W. Hesterberg, J. Carl Barrett, Kenneth B. Adler
Pages 221-227
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- Patricia M. Hinkle, Jane Halpern, Patricia A. Kinsella, Risa A. Freedman
Pages 229-242
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About this book
This book is based on reviews and research presentations given at the 16th Rochester International Conference on Environmental Toxicity, entitled liThe Cytoskeleton: A Target for Toxic Agents," held on June 4, 5 and 6 in 1984. The conference provided an in-depth discussion of the effects a~d mechanism of action of some toxic agents on the cytoskeleton. Mamma"lian and other eukaryotic cells contain protein networks within the cytoplasm comprised of microfilaments, intermediate Hlaments and microtubules. These components of the cytoskeleton playa key role in cell shape, motility, intracellular organization and transport, and cell division. Furthermore, the cytoskeleton, via associations with the cell membrane, appears to function in intracellular communication and cellular responses to membrane events. Because of the complex functional roles of the cytoskeleton which vary with cell type, degree of differentiation, and cell cycle, its disruption may result in a variety of cellular changes. This expanding field in cell biology has already attracted the interest of toxicologists and environmental health scientists as a potentially fruitful area of research. Indeed, there is mounting evidence that certain toxic and chemotherapeutic compounds, as well as physical agents such as radiation and hydrostatic pressure, disrupt the normal structure and function of the cytoskeleton. This may be an important step in the overall expression of their action. It was, therefore, an opportune time to hold a conference to encourage the development of this area of toxicology and to suggest directions for future research.
Editors and Affiliations
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University of Rochester School of Medicine, Rochester, USA
Thomas W. Clarkson
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University of Connecticut Health Center, Farmington, USA
Polly R. Sager
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University of Trondheim Faculty of Medicine, Trondheim, Norway
Tore L. M. Syversen