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Advances in Drug Development for Acute Migraine

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Abstract

Triptans revolutionized medical recognition and the acute treatment of migraine. Yet, throughout a lifetime, millions of patients who live with migraine endure hundreds of days of disability due to their disease. Most migraine attacks respond to migraine-specific interventions, but attack response does not predict patient response. Generally, migraine patients respond to acute treatment for some, but not necessarily all, attacks of migraine. Consequently, there remains a substantial unmet clinical need for better acute treatment of migraine.

Numerous avenues of research and clinical observation provide insight into potential advances in acute treatment of migraine. These include better delivery systems for existing drugs, as well as the development of potential new therapeutic agents. In addition, new changes in migraine taxonomy and clinical observations of migraine suggest additional important therapeutic opportunities. Based on clinical observations, this article explores future acute treatment needs, drugs in development for acute migraine, and new products that deliver established drugs to improve treatment response.

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Acknowledgements

The authors received no external funding or support for the preparation of this manuscript. The authors wish to acknowledge the contributions of Jessica Hall for assistance with writing the manuscript.

Dr Roger Cady currently serves on several advisory boards: Allergan, Astellas, MAP Pharmaceuticals, Merck & Co, Inc., Novartis, Ortho-McNeil Neurologics and Zogenix. He also receives research grants from Allergan, Boston Scientific, Bristol Myers, GlaxoSmithKline, Merck & Co., Inc., Opti Nose, Pura Med Bioscience and Zogenix. Dr Cady has provided consulting services for Allergan, Astellas, GlaxoSmithKline, Merck & Co., Inc. and Ortho-McNeil Neurologics.

Candace Shade has no conflicts of interest that are directly relevant to the content of this article. Ryan Cady has no conflicts of interest that are directly relevant to the content of this article.

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  1. Center of Biomedical & Life Sciences, Missouri State University, Springfield, MO, USA

    Ryan J. Cady

  2. Banyan Group, Inc., 3805 S. Kansas Expressway, Springfield, MO, 65807, USA

    Candace L. Shade &  Roger K. Cady M.D.

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  1. Ryan J. Cady
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  2. Candace L. Shade
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  3. Roger K. Cady M.D.
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Correspondence to Roger K. Cady M.D..

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Cady, R.J., Shade, C.L. & Cady, R.K. Advances in Drug Development for Acute Migraine. Drugs 72, 2187–2205 (2012). https://doi.org/10.2165/11641120-000000000-00000

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