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Effect of Dexmedetomidine on Haemodynamic Responses to Laryngoscopy and Intubation

Perioperative Haemodynamics and Anaesthetic Requirements

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Abstract

Background: Dexmedetomidine reduces the dose requirements for opioids and anaesthetic agents. The purpose of this study was to evaluate the effect of a single pre-induction intravenous dose of dexmedetomidine 1 μ/kg on cardiovascular response resulting from laryngoscopy and endotracheal intubation, need for anaesthetic agent and perioperative haemodynamic stability.

Methods: Fifty patients scheduled for elective minor surgery were randomised into two groups (dexmedetomidine group and placebo group, n = 25 in each group). During and after drug administration, the Ramsey sedation scale was applied every 5 minutes. Fentanyl 1 μ/kg was administered to all patients and thiopental was given until lash reflex disappeared. Anaesthesia continuation was maintained with 50% : 50%, oxygen : nitrous oxide. Sevoflurane concentration was adjusted to maintain systolic blood pressure within 20% of preoperative values. After extubation, the Steward awakening score was applied at 5 and 10 minutes. Haemodynamic parameters and adverse effects were recorded every 10 minutes for 1 hour after surgery.

Results: During intubation the need for thiopental and sevoflurane concentration were decreased by 39% and 92%, respectively, in the dexmedetomidine group compared with the placebo group. In all groups, blood pressure and heart rate increased after tracheal intubation; both were significantly lower in the dexmedetomidine group than in the placebo group (p < 0.05). Fentanyl requirement during the operation was 74.20 ± 10.53μg in the dexmedetomidine group and 84.00 ± 27.04μg in the placebo group (p < 0.05). At 5 minutes, the Steward scores were >6 in 56% of the dexmedetomidine group and in 4% of the placebo group (p < 0.05). At 10 minutes, sedation scores were ≥4 in all patients in the dexmedetomidine group (p < 0.05). Arterial blood pressure and heart rate in the postoperative period were significantly lower in the dexmedetomidine group compared with the placebo group (p < 0.05).

Conclusion: Preoperative administration of a single dose of dexmedetomidine resulted in progressive increases in sedation, blunted the haemodynamic responses during laryngoscopy, and reduced opioid and anaesthetic requirements. Furthermore, dexmedetomidine decreased blood pressure and heart rate as well as the recovery time after the operation.

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Acknowledgements

The authors thank Dr Fatih Kora for his contributions to the statistical analysis. No funding was received for this study, and the authors have no potential conflicts of interest that are directly relevant to the contents of this manuscript.

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  1. Department of Anaesthesiology, Medical Faculty, University of Selcuk of Meram, TR-42080, Konya, Turkey

    Munise Yildiz,  Aybars Tavlan, Sema Tuncer, Ruhiye Reisli, Alper Yosunkaya & Seref Otelcioglu

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  1. Munise Yildiz
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  2. Aybars Tavlan
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  3. Sema Tuncer
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  4. Ruhiye Reisli
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Correspondence to Aybars Tavlan.

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Yildiz, M., Tavlan, A., Tuncer, S. et al. Effect of Dexmedetomidine on Haemodynamic Responses to Laryngoscopy and Intubation. Drugs R D 7, 43–52 (2006). https://doi.org/10.2165/00126839-200607010-00004

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