Abstract
The number of athletes self-administering ergogenic pharmacological agents to increase their competitive edge continues to be a problem. Most athletes using anabolic steroids (AS) have acquired a crude pharmacological database regarding these drugs. Their opinions regarding steroids have been derived from their subjective experiences and anecdotal information. For this reason, traditional warnings regarding the lack of efficacy and potential dangers of steroid misuse are disregarded. A common widely held opinion among bodybuilders is that the anabolic steroid experts are the athletic gurus who for years have utilised themselves as the experimental participants and then dispensed their empirical findings. This review will address the common anabolic steroid misconceptions held by many of today’s athletes by providing an evaluation of the scientific literature related to AS in athletic performance.
Similar content being viewed by others
References
Dawson RT. Drugs in sports: the role of the physician. J Endocrinol 2001; 170: 55–61
Maharaj VR, Dookie T, Mohammed S, et al. Knowledge, attitudes and practices of anabolic steroid usage among gym users in Trinidad. West Indian Med J 2000; 49: 55–8
Blue JG, Lombardo JA. Steroids and steroid-like compounds. Clin Sports Med 1999; 18: 667–89
Silver MD. Use of ergogenic aids by athletes. J Am Acad Orthop Surg 2001; 9: 61–70
Wood AJ. Androgens in men: uses and misuses. N Engl J Med 1996; 334: 707–14
Yates WR, Perry PJ, Anderson KH. Illicit anabolic steroid use: a controlled personality study. Acta Psychiatr Scand 1990; 81: 548–50
Blue Cross and Blue Shield Association. Health Competition Foundation National survey on performance enhancing drugs in sports. Blue Cross and Blue Shield Association [online]. Available from URL: http://www.bcbs.com [Accessed 2001 Jan 1]
Sullivan ML, Martinez CM, Gennis P, et al. The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis 1998; 41: 1–15
Faigenbaum AD, Zaichkowsky LD, et al. Anabolic steroid use by male and female middle school students [abstract]. Pediatrics 1998; 101 (5): E6
Yesalis CE, Bahrke MS. Anabolic-androgenic steroids: current issues. Sports Med 1995; 19: 326–40
Buckley WE, Yesalis CE, Bennell DL. Astudy of anabolic steroid use at the secondary school level: recommendations for prevention. In: Yesalis CE, editor. Anabolic steroids in sport and exercise. Champaign (IL): Human Kinetics Publishing, 1993: 71–86
Green GA, Uryasz FD, Petr TA, et al. NCAA study of substance use and misuse habits of college student-athletes. Clin J Sport Med 2001; 11: 51–6
Yesalis CE, Buckley WE, Anderson WA, et al. Athletes’ projections of anabolic steroid use. Clin Sports Med 1990; 2: 155–71
Yesalis CE, Herrick R, Buckley W, et al. Self-reported use of anabolic-androgenic steroids by elite power lifters. Physician Sportmed 1988; 16: 91–100
Tricker R, O’Neill M, Cook D. The incidence of anabolic steroid use among competitive body builders. J Drug Educ 1989; 19: 313–25
Verroken M. Ethical aspects and the prevalence of hormone abuse in sport. J Endocrinol 2001; 170: 9–54
Kadi F, Eriksson A, Holmer S, et al.Effects of anabolic steroids on the muscle cells of strength trained athletes. Med Sci Sports Exerc 1999; 31: 1528–34
Sheffield-Moore M. Androgens and the control of skeletal muscle protein synthesis. Ann Med 2000; 32: 181–6
Kadi F. Adaptation of human skeletal muscle to training and anabolic steroids. Acta Physiol Scand Suppl 2000; 646: 1–52
Haupt HA, Rovere GD. Anabolic steroids: a review of the literature. Am J Sports Med 1984; 12: 469–84
Bhasin S, Storer TW, Berman N, et al. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 1996; 335: 1–7
Mayer M, Rosen F. Interaction of anabolic steroids with glucocorticoid receptor sites in rat muscle cytosol. Am J Physiol 1975; 229: 1381–6
Rubinow DR, Schmidt PJ. Androgens, brain, and behavior. Am J Psychiatry 1996; 153: 974–84
Lamb DR. Anabolic steroids in athletics: how well do they work and how dangerous are they? Am J Sports Med 1984; 12: 31–8
Ariel G, Saville W. Anabolic steroids: the physiological effects of placebos. Med Sci Sports 1972; 4: 124–6
Crist DM, Stackpole PJ, Peale GT. Effects of androgenic-anabolic steroids on neuromuscular power and body composition. J Appl Physiol 1983; 54: 366–70
Hickson RC, Ball KL, Falduto MT. Adverse effects of anabolic steroids. Med Toxicol Adverse Drug Exp 1989; 4: 254–71
Freed DL, Banks AJ, Longson D, et al. Anabolic steroids in athletics: crossover double-blind trial on weightlifters. BMJ 1975; 2: 471–3
Perry PJ, Anderson KH, Yates WR. Illicit anabolic steroid use in athletes: a case series analysis. Am J Sports Med 1990; 18: 422–8
Gill GV. Anabolic steroid induced hypogonadism treated with human chorionic gonadotropin. Postgrad Med J 1998; 74: 45–6
Hervey GR, Knibbs AV, Burkenshaw L, et al. Effects of methandienone on the performance and body composition of men undergoing athletic training. Clin Sci 1981; 60: 457–61
Duchaine D. Underground steroid handbook II. Venice (CA): HLR Technical Books, 1989
Sader MA, Griffiths KA, McCredie RJ, et al. Androgenic anabolic steroids and arterial structure and function in male bodybuilders. J Am Coll Cardiol 2001; 37: 224–30
Ishak KG, Zimmerman HJ. Hepatotoxic effects of the anabolic/androgenic steroids. Semin Liver Dis 1987; 7: 230–6
Glazer G. Arthrogenic effects of anabolic steroids on serum lipid levels. Arch Intern Med 1991; 151: 1925–33
Koenig H, Goldstone A, Lu CY. Testosterone-mediated sexual dimorphism of the rodent heart: ventricular lysosomes, mitochondria, and cell growth are modulated by androgens. Circulation 1982; 50: 782–7
Jarow JP, Lipshultz LI. Anabolic steroid-induced hypogonadotropic hypogonadism. Am J Sports Med 1990; 18: 429–31
MacIndoe JH, Perry PJ, Yates WR, et al. Testosterone suppression of the HPT axis. J Invest Med 1997; 45: 441–7
Holma PK. Effects of an anabolic steroid (metandienone) on spermatogenesis. Contraception 1977; 15: 151–62
Yates WR, Perry PJ, MacIndoe J, et al. Psychosexual effects of three doses of testosterone cycling in normal men. Biol Psychiatry 1999; 45: 254–60
Turek PJ, Williams RH, Gilbauch JH, et al. The reversibility of anabolic steroid-induced azospermia. J Urol 1995; 153: 1628–30
Straus RH, Liggett MT, Lanese RR. Anabolic steroid use and perceived effects in ten weight-trained women athletes. JAMA 1985; 253: 2871–3
Conacher GN, Workman DG. Violent crime possibly associated with anabolic steroid use. Am J Psychiatry 1989; 146: 679
Pope Jr HG, Katz DL. Affective and psychotic symptoms associated with anabolic steroid use. Am J Psychiatry 1988; 145: 487–90
Seidman SN, Spatz E, Rizzo C, et al. Testosterone replacement therapy of hypogonadal men with major depressive disorder: a randomized, placebo-controlled clinical trial. J Clin Psychiatry 2001; 62: 406–12
Kouri EM, Lukas SE, Pope Jr HG, et al. Increased aggressive responding in male volunteers following the administration of gradually increasing doses of testosterone cypionate. Drug Alcohol Depend 1995; 40: 73–9
Matsumoto AM. Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle stimulating hormone, and sperm production. J Clin Endocrinol Metab 1990; 70: 282–7
Pope Jr HG, Kouri EM, Hudson JI. Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial. Arch Gen Psychiatry 2000; 57: 133–40
Su TP, Pagliaro M, Schmidt PJ, et al. Neuropsychiatric effects of anabolic steroids in male normal volunteers. JAMA 1993; 269: 2760–4
Tricker R, Casaburi R, Strorer TW, et al. The effects of supraphysiological doses of testosterone on angry behavior in healthy eugonadal men-a clinical research center study. J Clin Endocrinol Metab 1996; 81: 3754–8
Yates WR, Perry PJ, Murray S. Aggression and hostility in anabolic steroid users. Biol Psychiatry 1992; 31: 1232–4
Pope Jr HG, Katz DL. Psychiatric and medical effects of anabolic- androgenic steroid use. Arch Gen Psychiatry 1994; 51: 375–82
Brower KJ, Blow FC, Young JP, et al. Symptoms and correlates of anabolic-androgenic steroid dependence. Br J Addict 1991; 86: 759–68
Copeland J, Peters R, et al. Anabolic-androgenic steroid use disorder among a sample of Australian competitive and recreational users. Drug Alcohol Depend 2000; 60: 91–6
Acknowledgements
The authors had no funding for this article and have no conflicts of interest that could affect its content.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kutscher, E.C., Lund, B.C. & Perry, P.J. Anabolic Steroids. Sports Med 32, 285–296 (2002). https://doi.org/10.2165/00007256-200232050-00001
Published:
Issue Date:
DOI: https://doi.org/10.2165/00007256-200232050-00001