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CD2+ Tetraploid Acute Promyelocytic Leukemia Variant with Double (15;17) Translocations

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Abstract

We report a patient with a variant form of CD2+ acute promyelocytic leukemia (APL) who had double translocations (15;17) in a single leukemic cell. The patient presented with severe neutropenia, thrombocytopenia, and disseminated intravascular coagulation. The bone marrow showed marked hyperplasia with large leukemic cells that had bizarre nuclear configuration and basophilic, hypogranular cytoplasm. Leukemic cells were positive for CD2, 13, 33, 34, and 56 and negative for HLA-DR.The karyotype of the abnormal clone was characterized as 92,XXYY, t(15;17)(q22;q21)x2. No other additional abnormal clone was found, and the patient’s condition was diagnosed as tetraploid APL variant. Fluorescence in situ hybridization assay revealed 2 promyelocytic leukemia and retinoic acid receptor α (PML/RARA) fusion signals, and reverse transcription-polymerase chain reaction assay revealed short-form PML/RARA fusion transcript. Tetraploidy in APL is a very rare abnormality. Double translocations were an additional abnormality in this case, and this patient’s karyotype might have had some influence on morphological characteristics, expression of CD2, and poor clinical outcome.

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Authors and Affiliations

  1. Central Clinical Laboratory, Jikei University Hospital, 3-19-18 Nishi Shinbashi, Minato-ku, 105-8471, Tokyo, Japan

    Ken Kaito

  2. Division of Hematology and Oncology, Department of Internal Medicine, Jikei University, School of Medicine, Tokyo, Japan

    Ken Kaito, Hiroko Otsubo, Nobuaki Dobashi, Noriko Usui & Masayuki Kobayashi

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  1. Ken Kaito
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  2. Hiroko Otsubo
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  3. Nobuaki Dobashi
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  4. Noriko Usui
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  5. Masayuki Kobayashi
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Correspondence to Ken Kaito.

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Kaito, K., Otsubo, H., Dobashi, N. et al. CD2+ Tetraploid Acute Promyelocytic Leukemia Variant with Double (15;17) Translocations. Int J Hematol 81, 29–31 (2005). https://doi.org/10.1532/IJH97.04104

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  • DOI: https://doi.org/10.1532/IJH97.04104

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