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Pathogenesis and Animal Models

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Rotaviruses

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 34))

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Abstract

Because of the limitations in studying human rotavirus (HRV) pathogenesis and mucosal immunity in the natural host (infants and children), various animal models have been utilized to investigate rotavirus (RV) disease pathogenesis and immunity. Mice and rabbits serve as useful models to evaluate and dissect immune responses to RV (see Chapter 9). However, because older mice (>14 d) and rabbits are not susceptible to diarrhea after inoculation with either homologous (murine or lapine, respectively) or heterologous (human) RVs, assessment of protective immunity is restricted to prevention of virus shedding only (1–3).

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Author information

Authors and Affiliations

  1. Food and Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH

    Linda J. Saif & Lucy A. Ward

Authors
  1. Linda J. Saif
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  2. Lucy A. Ward
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Editor information

Editors and Affiliations

  1. Clinical Microbiology and Public Health Laboratory Addenbrooke’s Hospital, Cambridge, UK

    James Gray  & Ulrich Desselberger  & 

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© 2000 Humana Press Inc., Totowa, NJ

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Saif, L.J., Ward, L.A. (2000). Pathogenesis and Animal Models. In: Gray, J., Desselberger, U. (eds) Rotaviruses. Methods in Molecular Medicine™, vol 34. Humana Press. https://doi.org/10.1385/1-59259-078-0:101

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  • DOI: https://doi.org/10.1385/1-59259-078-0:101

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-736-6

  • Online ISBN: 978-1-59259-078-0

  • eBook Packages: Springer Protocols

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